Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HMGB4Testis cDNA clone: QtsA-14017, similar to human HMG2 like (LOC127540). (191 aa)    
Predicted Functional Partners:
ENSMFAP00000001898
Uncharacterized protein.
   
  0.799
ENSMFAP00000004424
Uncharacterized protein.
   
  0.799
HMGB1
High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...]
   
  0.799
ENSMFAP00000042558
Uncharacterized protein.
   
  0.799
ENSMFAP00000045157
Uncharacterized protein.
   
  0.799
SP100
SP100 nuclear antigen.
    
  0.709
TLR4
Toll like receptor 4; Belongs to the Toll-like receptor family.
    
 0.685
AGER
Advanced glycosylation end-product specific receptor.
    
 0.659
SEC23IP
SEC23 interacting protein.
   
   0.655
PKNOX1
PBX/knotted 1 homeobox 1.
    
   0.628
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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