H2AX protein (Macaca fascicularis) - STRING interaction network

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Score

H2AX

Histone H2A; Belongs to the histone H2A family. (143 aa)

Predicted Functional Partners:

H2AC20

0.925

H2AC6

0.925

H3-4

0.921

RNF2

0.911

HIST2H2BE

0.909

G8F5U3_MACFA

0.906

H2BC3

0.903

ATM

0.903

H2BC18

0.902

H2BC5

0.897

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	G8F5U3_MACFA	ENSMFAP00000022390	ENSMFAP00000014408	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.585
ATM	H2AC20	ENSMFAP00000022390	ENSMFAP00000010058	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H2A; Belongs to the histone H2A family.	0.659
ATM	H2AC6	ENSMFAP00000022390	ENSMFAP00000010783	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H2A; Belongs to the histone H2A family.	0.563
ATM	H2AX	ENSMFAP00000022390	ENSMFAP00000010696	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H2A; Belongs to the histone H2A family.	0.903
ATM	H3-4	ENSMFAP00000022390	ENSMFAP00000012149	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.600
ATM	HIST2H2BE	ENSMFAP00000022390	ENSMFAP00000014350	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H2B; Belongs to the histone H2B family.	0.448
G8F5U3_MACFA	ATM	ENSMFAP00000014408	ENSMFAP00000022390	Histone H3; Belongs to the histone H3 family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.585
G8F5U3_MACFA	H2AC20	ENSMFAP00000014408	ENSMFAP00000010058	Histone H3; Belongs to the histone H3 family.	Histone H2A; Belongs to the histone H2A family.	0.908
G8F5U3_MACFA	H2AC6	ENSMFAP00000014408	ENSMFAP00000010783	Histone H3; Belongs to the histone H3 family.	Histone H2A; Belongs to the histone H2A family.	0.930
G8F5U3_MACFA	H2AX	ENSMFAP00000014408	ENSMFAP00000010696	Histone H3; Belongs to the histone H3 family.	Histone H2A; Belongs to the histone H2A family.	0.906
G8F5U3_MACFA	H2BC18	ENSMFAP00000014408	ENSMFAP00000033816	Histone H3; Belongs to the histone H3 family.	Histone H2B; Belongs to the histone H2B family.	0.924
G8F5U3_MACFA	H2BC3	ENSMFAP00000014408	ENSMFAP00000014039	Histone H3; Belongs to the histone H3 family.	Histone H2B; Belongs to the histone H2B family.	0.886
G8F5U3_MACFA	H2BC5	ENSMFAP00000014408	ENSMFAP00000013356	Histone H3; Belongs to the histone H3 family.	Histone H2B; Belongs to the histone H2B family.	0.877
G8F5U3_MACFA	H3-4	ENSMFAP00000014408	ENSMFAP00000012149	Histone H3; Belongs to the histone H3 family.	Histone H3; Belongs to the histone H3 family.	0.903
G8F5U3_MACFA	HIST2H2BE	ENSMFAP00000014408	ENSMFAP00000014350	Histone H3; Belongs to the histone H3 family.	Histone H2B; Belongs to the histone H2B family.	0.907
G8F5U3_MACFA	RNF2	ENSMFAP00000014408	ENSMFAP00000007395	Histone H3; Belongs to the histone H3 family.	Ring finger protein 2.	0.677
H2AC20	ATM	ENSMFAP00000010058	ENSMFAP00000022390	Histone H2A; Belongs to the histone H2A family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.659
H2AC20	G8F5U3_MACFA	ENSMFAP00000010058	ENSMFAP00000014408	Histone H2A; Belongs to the histone H2A family.	Histone H3; Belongs to the histone H3 family.	0.908
H2AC20	H2AC6	ENSMFAP00000010058	ENSMFAP00000010783	Histone H2A; Belongs to the histone H2A family.	Histone H2A; Belongs to the histone H2A family.	0.990
H2AC20	H2AX	ENSMFAP00000010058	ENSMFAP00000010696	Histone H2A; Belongs to the histone H2A family.	Histone H2A; Belongs to the histone H2A family.	0.925

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