| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ENSMFAP00000004513 | MAD2L2 | ENSMFAP00000004513 | ENSMFAP00000040124 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Mitotic arrest deficient 2 like 2. | 0.768 |
| ENSMFAP00000004513 | POLH | ENSMFAP00000004513 | ENSMFAP00000028495 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA polymerase eta. | 0.946 |
| ENSMFAP00000004513 | POLI | ENSMFAP00000004513 | ENSMFAP00000011018 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA polymerase iota. | 0.918 |
| ENSMFAP00000004513 | POLL | ENSMFAP00000004513 | ENSMFAP00000022802 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.866 |
| ENSMFAP00000004513 | REV1 | ENSMFAP00000004513 | ENSMFAP00000023813 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. | 0.946 |
| ENSMFAP00000004513 | REV3L | ENSMFAP00000004513 | ENSMFAP00000000822 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | REV3 like, DNA directed polymerase zeta catalytic subunit. | 0.902 |
| ENSMFAP00000004513 | TP53 | ENSMFAP00000004513 | ENSMFAP00000038526 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.904 |
| ENSMFAP00000004513 | UBB | ENSMFAP00000004513 | ENSMFAP00000040895 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Uncharacterized protein. | 0.795 |
| ENSMFAP00000004513 | UBC | ENSMFAP00000004513 | ENSMFAP00000010479 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | Ubiquitin C. | 0.737 |
| MAD2L2 | ENSMFAP00000004513 | ENSMFAP00000040124 | ENSMFAP00000004513 | Mitotic arrest deficient 2 like 2. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.768 |
| MAD2L2 | PCNA | ENSMFAP00000040124 | ENSMFAP00000031561 | Mitotic arrest deficient 2 like 2. | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | 0.768 |
| MAD2L2 | POLH | ENSMFAP00000040124 | ENSMFAP00000028495 | Mitotic arrest deficient 2 like 2. | DNA polymerase eta. | 0.899 |
| MAD2L2 | POLI | ENSMFAP00000040124 | ENSMFAP00000011018 | Mitotic arrest deficient 2 like 2. | DNA polymerase iota. | 0.880 |
| MAD2L2 | POLL | ENSMFAP00000040124 | ENSMFAP00000022802 | Mitotic arrest deficient 2 like 2. | DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.464 |
| MAD2L2 | REV1 | ENSMFAP00000040124 | ENSMFAP00000023813 | Mitotic arrest deficient 2 like 2. | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. | 0.989 |
| MAD2L2 | REV3L | ENSMFAP00000040124 | ENSMFAP00000000822 | Mitotic arrest deficient 2 like 2. | REV3 like, DNA directed polymerase zeta catalytic subunit. | 0.998 |
| MAD2L2 | UBB | ENSMFAP00000040124 | ENSMFAP00000040895 | Mitotic arrest deficient 2 like 2. | Uncharacterized protein. | 0.481 |
| MAD2L2 | UBC | ENSMFAP00000040124 | ENSMFAP00000010479 | Mitotic arrest deficient 2 like 2. | Ubiquitin C. | 0.481 |
| PCNA | MAD2L2 | ENSMFAP00000031561 | ENSMFAP00000040124 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | Mitotic arrest deficient 2 like 2. | 0.768 |
| PCNA | POLH | ENSMFAP00000031561 | ENSMFAP00000028495 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] | DNA polymerase eta. | 0.946 |
