| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ARRB1 | ARRB2 | ENSMFAP00000031367 | ENSMFAP00000008309 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Arrestin beta 2. | 0.994 |
| ARRB1 | GNAI1 | ENSMFAP00000031367 | ENSMFAP00000008751 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | G protein subunit alpha i1. | 0.438 |
| ARRB1 | GNB4 | ENSMFAP00000031367 | ENSMFAP00000041549 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | G protein subunit beta 4. | 0.638 |
| ARRB1 | GNG2 | ENSMFAP00000031367 | ENSMFAP00000037001 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.599 |
| ARRB1 | GPR1 | ENSMFAP00000031367 | ENSMFAP00000011154 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.790 |
| ARRB1 | RARRES2 | ENSMFAP00000031367 | ENSMFAP00000023449 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | Retinoic acid receptor responder 2. | 0.578 |
| ARRB2 | ARRB1 | ENSMFAP00000008309 | ENSMFAP00000031367 | Arrestin beta 2. | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | 0.994 |
| ARRB2 | GNB4 | ENSMFAP00000008309 | ENSMFAP00000041549 | Arrestin beta 2. | G protein subunit beta 4. | 0.441 |
| ARRB2 | GPR1 | ENSMFAP00000008309 | ENSMFAP00000011154 | Arrestin beta 2. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.618 |
| CCRL2 | GPR1 | ENSMFAP00000032289 | ENSMFAP00000011154 | C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.563 |
| CCRL2 | RARRES2 | ENSMFAP00000032289 | ENSMFAP00000023449 | C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. | Retinoic acid receptor responder 2. | 0.580 |
| GNAI1 | ARRB1 | ENSMFAP00000008751 | ENSMFAP00000031367 | G protein subunit alpha i1. | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] | 0.438 |
| GNAI1 | GNAI3 | ENSMFAP00000008751 | ENSMFAP00000037022 | G protein subunit alpha i1. | G protein subunit alpha i3. | 0.900 |
| GNAI1 | GNB4 | ENSMFAP00000008751 | ENSMFAP00000041549 | G protein subunit alpha i1. | G protein subunit beta 4. | 0.944 |
| GNAI1 | GNG2 | ENSMFAP00000008751 | ENSMFAP00000037001 | G protein subunit alpha i1. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.982 |
| GNAI1 | GPR1 | ENSMFAP00000008751 | ENSMFAP00000011154 | G protein subunit alpha i1. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.559 |
| GNAI3 | GNAI1 | ENSMFAP00000037022 | ENSMFAP00000008751 | G protein subunit alpha i3. | G protein subunit alpha i1. | 0.900 |
| GNAI3 | GNB4 | ENSMFAP00000037022 | ENSMFAP00000041549 | G protein subunit alpha i3. | G protein subunit beta 4. | 0.944 |
| GNAI3 | GNG2 | ENSMFAP00000037022 | ENSMFAP00000037001 | G protein subunit alpha i3. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.915 |
| GNAI3 | GPR1 | ENSMFAP00000037022 | ENSMFAP00000011154 | G protein subunit alpha i3. | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (By similarity). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). | 0.559 |
