KCNU1 protein (Macaca fascicularis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

KCNU1

Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina (By similarity); Belongs to the potassium channel fa [...] (1149 aa)

Predicted Functional Partners:

KCNMB1

0.991

KCNMB4

0.956

KCNN4

0.952

KCNMB2

0.946

KCNMB3

0.938

KCNN1

0.936

PRKACA

0.936

PRKACG

0.936

PRKACB

0.936

KCNN3

0.936

Your Current Organism:

Macaca fascicularis

NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCNMB1	KCNMB2	ENSMFAP00000005500	ENSMFAP00000037203	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	KcnmB2_inactiv domain-containing protein.	0.908
KCNMB1	KCNMB3	ENSMFAP00000005500	ENSMFAP00000006827	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Potassium calcium-activated channel subfamily M regulatory beta subunit 3.	0.933
KCNMB1	KCNMB4	ENSMFAP00000005500	ENSMFAP00000026938	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Potassium calcium-activated channel subfamily M regulatory beta subunit 4.	0.957
KCNMB1	KCNN1	ENSMFAP00000005500	ENSMFAP00000001673	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Potassium calcium-activated channel subfamily N member 1.	0.921
KCNMB1	KCNN3	ENSMFAP00000005500	ENSMFAP00000042752	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Potassium calcium-activated channel subfamily N member 3.	0.921
KCNMB1	KCNN4	ENSMFAP00000005500	ENSMFAP00000038156	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Potassium calcium-activated channel subfamily N member 4.	0.921
KCNMB1	KCNU1	ENSMFAP00000005500	ENSMFAP00000011367	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina (By similarity); Belongs to the potassium channel fa [...]	0.991
KCNMB1	PRKACA	ENSMFAP00000005500	ENSMFAP00000009922	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.905
KCNMB1	PRKACB	ENSMFAP00000005500	ENSMFAP00000025214	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.905
KCNMB1	PRKACG	ENSMFAP00000005500	ENSMFAP00000014434	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.905
KCNMB2	KCNMB1	ENSMFAP00000037203	ENSMFAP00000005500	KcnmB2_inactiv domain-containing protein.	Potassium calcium-activated channel subfamily M regulatory beta subunit 1.	0.908
KCNMB2	KCNMB3	ENSMFAP00000037203	ENSMFAP00000006827	KcnmB2_inactiv domain-containing protein.	Potassium calcium-activated channel subfamily M regulatory beta subunit 3.	0.909
KCNMB2	KCNMB4	ENSMFAP00000037203	ENSMFAP00000026938	KcnmB2_inactiv domain-containing protein.	Potassium calcium-activated channel subfamily M regulatory beta subunit 4.	0.914
KCNMB2	KCNN1	ENSMFAP00000037203	ENSMFAP00000001673	KcnmB2_inactiv domain-containing protein.	Potassium calcium-activated channel subfamily N member 1.	0.920
KCNMB2	KCNN3	ENSMFAP00000037203	ENSMFAP00000042752	KcnmB2_inactiv domain-containing protein.	Potassium calcium-activated channel subfamily N member 3.	0.917
KCNMB2	KCNN4	ENSMFAP00000037203	ENSMFAP00000038156	KcnmB2_inactiv domain-containing protein.	Potassium calcium-activated channel subfamily N member 4.	0.910
KCNMB2	KCNU1	ENSMFAP00000037203	ENSMFAP00000011367	KcnmB2_inactiv domain-containing protein.	Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina (By similarity); Belongs to the potassium channel fa [...]	0.946
KCNMB2	PRKACA	ENSMFAP00000037203	ENSMFAP00000009922	KcnmB2_inactiv domain-containing protein.	Protein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily.	0.900
KCNMB2	PRKACB	ENSMFAP00000037203	ENSMFAP00000025214	KcnmB2_inactiv domain-containing protein.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.900
KCNMB2	PRKACG	ENSMFAP00000037203	ENSMFAP00000014434	KcnmB2_inactiv domain-containing protein.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.900

page 1 of 5

Server load: low (18%) [HD]

Permalink

Network

Co-occurrence

Experiments

Co-expression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2026

Credits

Access

Info

About