node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | CS | ENSMFAP00000004443 | ENSMFAP00000004989 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.997 |
ACLY | ENSMFAP00000011534 | ENSMFAP00000004443 | ENSMFAP00000011534 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | 0.495 |
ACLY | ENSMFAP00000033177 | ENSMFAP00000004443 | ENSMFAP00000033177 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.739 |
ACLY | FH | ENSMFAP00000004443 | ENSMFAP00000028430 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] | 0.720 |
ACLY | IDH1 | ENSMFAP00000004443 | ENSMFAP00000037246 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.739 |
ACLY | IDH2 | ENSMFAP00000004443 | ENSMFAP00000002582 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.739 |
ACLY | SDHA | ENSMFAP00000004443 | ENSMFAP00000011190 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.953 |
ACLY | SUCLG1 | ENSMFAP00000004443 | ENSMFAP00000023185 | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.984 |
CS | ACLY | ENSMFAP00000004989 | ENSMFAP00000004443 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.997 |
CS | ENSMFAP00000011534 | ENSMFAP00000004989 | ENSMFAP00000011534 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | 0.709 |
CS | ENSMFAP00000033177 | ENSMFAP00000004989 | ENSMFAP00000033177 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.906 |
CS | FH | ENSMFAP00000004989 | ENSMFAP00000028430 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] | 0.961 |
CS | GPT | ENSMFAP00000004989 | ENSMFAP00000029444 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Glutamic--pyruvic transaminase. | 0.439 |
CS | GPT2 | ENSMFAP00000004989 | ENSMFAP00000020197 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Glutamic--pyruvic transaminase 2. | 0.439 |
CS | IDH1 | ENSMFAP00000004989 | ENSMFAP00000037246 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.948 |
CS | IDH2 | ENSMFAP00000004989 | ENSMFAP00000002582 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. | 0.949 |
CS | SDHA | ENSMFAP00000004989 | ENSMFAP00000011190 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. | 0.981 |
CS | SUCLG1 | ENSMFAP00000004989 | ENSMFAP00000023185 | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. | 0.920 |
ENSMFAP00000011534 | ACLY | ENSMFAP00000011534 | ENSMFAP00000004443 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. | 0.495 |
ENSMFAP00000011534 | CS | ENSMFAP00000011534 | ENSMFAP00000004989 | L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. | Citrate synthase, mitochondrial; Belongs to the citrate synthase family. | 0.709 |