node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSF2 | CSF2RB | ENSMFAP00000012442 | ENSMFAP00000025568 | Colony stimulating factor 2. | Colony stimulating factor 2 receptor beta common subunit. | 0.995 |
CSF2 | IFNG | ENSMFAP00000012442 | ENSMFAP00000024297 | Colony stimulating factor 2. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.910 |
CSF2 | IL13 | ENSMFAP00000012442 | ENSMFAP00000015652 | Colony stimulating factor 2. | Interleukin 13. | 0.906 |
CSF2 | IL1B | ENSMFAP00000012442 | ENSMFAP00000022744 | Colony stimulating factor 2. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.918 |
CSF2 | IL2 | ENSMFAP00000012442 | ENSMFAP00000021866 | Colony stimulating factor 2. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.932 |
CSF2 | IL5RA | ENSMFAP00000012442 | ENSMFAP00000010231 | Colony stimulating factor 2. | Interleukin 5 receptor alpha. | 0.903 |
CSF2 | IL6 | ENSMFAP00000012442 | ENSMFAP00000045012 | Colony stimulating factor 2. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.900 |
CSF2 | LOC102139775 | ENSMFAP00000012442 | ENSMFAP00000009959 | Colony stimulating factor 2. | Fibronectin type-III domain-containing protein. | 0.955 |
CSF2 | LOC102147050 | ENSMFAP00000012442 | ENSMFAP00000011450 | Colony stimulating factor 2. | Uncharacterized protein. | 0.955 |
CSF2 | RUNX1 | ENSMFAP00000012442 | ENSMFAP00000019622 | Colony stimulating factor 2. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.927 |
CSF2RB | CSF2 | ENSMFAP00000025568 | ENSMFAP00000012442 | Colony stimulating factor 2 receptor beta common subunit. | Colony stimulating factor 2. | 0.995 |
CSF2RB | IFNG | ENSMFAP00000025568 | ENSMFAP00000024297 | Colony stimulating factor 2 receptor beta common subunit. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.697 |
CSF2RB | IL13 | ENSMFAP00000025568 | ENSMFAP00000015652 | Colony stimulating factor 2 receptor beta common subunit. | Interleukin 13. | 0.693 |
CSF2RB | IL2 | ENSMFAP00000025568 | ENSMFAP00000021866 | Colony stimulating factor 2 receptor beta common subunit. | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells (By similarity); Belongs to the IL-2 family. | 0.724 |
CSF2RB | IL5RA | ENSMFAP00000025568 | ENSMFAP00000010231 | Colony stimulating factor 2 receptor beta common subunit. | Interleukin 5 receptor alpha. | 0.950 |
CSF2RB | IL6 | ENSMFAP00000025568 | ENSMFAP00000045012 | Colony stimulating factor 2 receptor beta common subunit. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.739 |
CSF2RB | LOC102139775 | ENSMFAP00000025568 | ENSMFAP00000009959 | Colony stimulating factor 2 receptor beta common subunit. | Fibronectin type-III domain-containing protein. | 0.925 |
CSF2RB | LOC102147050 | ENSMFAP00000025568 | ENSMFAP00000011450 | Colony stimulating factor 2 receptor beta common subunit. | Uncharacterized protein. | 0.925 |
IFNG | CSF2 | ENSMFAP00000024297 | ENSMFAP00000012442 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Colony stimulating factor 2. | 0.910 |
IFNG | CSF2RB | ENSMFAP00000024297 | ENSMFAP00000025568 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Colony stimulating factor 2 receptor beta common subunit. | 0.697 |