STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPTA1Spectrin alpha, erythrocytic 1. (2420 aa)    
Predicted Functional Partners:
SPTB
Spectrin beta chain; Belongs to the spectrin family.
   
0.974
SPTAN1
Spectrin alpha, non-erythrocytic 1.
  
  
 
0.929
ITSN2
Intersectin 2.
   
 
 0.925
CASP3
Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family.
    
 0.925
SPTBN1
Spectrin beta chain; Belongs to the spectrin family.
   
0.898
RHAG
Rh associated glycoprotein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
   
  
 0.866
SPTBN2
Spectrin beta chain; Belongs to the spectrin family.
   
0.864
SPTBN5
Spectrin beta, non-erythrocytic 5.
   
0.833
SPTBN4
Spectrin beta chain; Belongs to the spectrin family.
   
0.830
EPB42
Erythrocyte membrane protein band 4.2.
   
 
 0.727
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.