node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP3 | CHRD | ENSMFAP00000019482 | ENSMFAP00000004245 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. | 0.672 |
BMP3 | FGF13 | ENSMFAP00000019482 | ENSMFAP00000014802 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.616 |
CHRD | BMP3 | ENSMFAP00000004245 | ENSMFAP00000019482 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. | Bone morphogenetic protein 3; Belongs to the TGF-beta family. | 0.672 |
CHRD | FGF13 | ENSMFAP00000004245 | ENSMFAP00000014802 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.615 |
EGF | FGF13 | ENSMFAP00000034472 | ENSMFAP00000014802 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.693 |
EGF | FGFR1 | ENSMFAP00000034472 | ENSMFAP00000036901 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Fibroblast growth factor receptor. | 0.820 |
EGF | FGFR2 | ENSMFAP00000034472 | ENSMFAP00000000798 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Fibroblast growth factor receptor. | 0.799 |
EGF | FGFR3 | ENSMFAP00000034472 | ENSMFAP00000018681 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Fibroblast growth factor receptor. | 0.798 |
EGF | FGFR4 | ENSMFAP00000034472 | ENSMFAP00000019333 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | Fibroblast growth factor receptor. | 0.717 |
FGF13 | BMP3 | ENSMFAP00000014802 | ENSMFAP00000019482 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Bone morphogenetic protein 3; Belongs to the TGF-beta family. | 0.616 |
FGF13 | CHRD | ENSMFAP00000014802 | ENSMFAP00000004245 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. | 0.615 |
FGF13 | EGF | ENSMFAP00000014802 | ENSMFAP00000034472 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.693 |
FGF13 | FGFR1 | ENSMFAP00000014802 | ENSMFAP00000036901 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.625 |
FGF13 | FGFR2 | ENSMFAP00000014802 | ENSMFAP00000000798 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.702 |
FGF13 | FGFR3 | ENSMFAP00000014802 | ENSMFAP00000018681 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.625 |
FGF13 | FGFR4 | ENSMFAP00000014802 | ENSMFAP00000019333 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Fibroblast growth factor receptor. | 0.625 |
FGF13 | KL | ENSMFAP00000014802 | ENSMFAP00000021797 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). | 0.681 |
FGF13 | SCN3A | ENSMFAP00000014802 | ENSMFAP00000027626 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.697 |
FGF13 | SCN5A | ENSMFAP00000014802 | ENSMFAP00000042408 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. | 0.832 |
FGFR1 | EGF | ENSMFAP00000036901 | ENSMFAP00000034472 | Fibroblast growth factor receptor. | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. | 0.820 |