node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHUK | DDX58 | ENSMFAP00000045663 | ENSMFAP00000028638 | Component of inhibitor of nuclear factor kappa B kinase complex. | DExD/H-box helicase 58. | 0.410 |
CHUK | EIF2AK1 | ENSMFAP00000045663 | ENSMFAP00000044852 | Component of inhibitor of nuclear factor kappa B kinase complex. | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | 0.908 |
CHUK | EIF2AK2 | ENSMFAP00000045663 | ENSMFAP00000014830 | Component of inhibitor of nuclear factor kappa B kinase complex. | Eukaryotic translation initiation factor 2 alpha kinase 2. | 0.944 |
CHUK | FADD | ENSMFAP00000045663 | ENSMFAP00000028867 | Component of inhibitor of nuclear factor kappa B kinase complex. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.614 |
CHUK | IKBKB | ENSMFAP00000045663 | ENSMFAP00000042091 | Component of inhibitor of nuclear factor kappa B kinase complex. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.999 |
CHUK | RIPK1 | ENSMFAP00000045663 | ENSMFAP00000032187 | Component of inhibitor of nuclear factor kappa B kinase complex. | Receptor interacting serine/threonine kinase 1. | 0.982 |
DDX58 | CHUK | ENSMFAP00000028638 | ENSMFAP00000045663 | DExD/H-box helicase 58. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.410 |
DDX58 | EIF2AK2 | ENSMFAP00000028638 | ENSMFAP00000014830 | DExD/H-box helicase 58. | Eukaryotic translation initiation factor 2 alpha kinase 2. | 0.947 |
DDX58 | FADD | ENSMFAP00000028638 | ENSMFAP00000028867 | DExD/H-box helicase 58. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.471 |
DDX58 | IKBKB | ENSMFAP00000028638 | ENSMFAP00000042091 | DExD/H-box helicase 58. | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.406 |
DDX58 | ISG15 | ENSMFAP00000028638 | ENSMFAP00000041264 | DExD/H-box helicase 58. | ISG15 ubiquitin like modifier. | 0.994 |
DDX58 | RIPK1 | ENSMFAP00000028638 | ENSMFAP00000032187 | DExD/H-box helicase 58. | Receptor interacting serine/threonine kinase 1. | 0.646 |
DNAJC3 | EIF2AK2 | ENSMFAP00000036159 | ENSMFAP00000014830 | DnaJ heat shock protein family (Hsp40) member C3. | Eukaryotic translation initiation factor 2 alpha kinase 2. | 0.958 |
DNAJC3 | EIF2S1 | ENSMFAP00000036159 | ENSMFAP00000036872 | DnaJ heat shock protein family (Hsp40) member C3. | Eukaryotic translation initiation factor 2 subunit alpha. | 0.414 |
EIF2AK1 | CHUK | ENSMFAP00000044852 | ENSMFAP00000045663 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.908 |
EIF2AK1 | EIF2AK2 | ENSMFAP00000044852 | ENSMFAP00000014830 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Eukaryotic translation initiation factor 2 alpha kinase 2. | 0.945 |
EIF2AK1 | EIF2S1 | ENSMFAP00000044852 | ENSMFAP00000036872 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Eukaryotic translation initiation factor 2 subunit alpha. | 0.989 |
EIF2AK1 | IKBKB | ENSMFAP00000044852 | ENSMFAP00000042091 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Inhibitor of nuclear factor kappa B kinase subunit beta. | 0.909 |
EIF2AK1 | NFE2L2 | ENSMFAP00000044852 | ENSMFAP00000040664 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser- 51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-se [...] | Nuclear factor, erythroid 2 like 2. | 0.902 |
EIF2AK2 | CHUK | ENSMFAP00000014830 | ENSMFAP00000045663 | Eukaryotic translation initiation factor 2 alpha kinase 2. | Component of inhibitor of nuclear factor kappa B kinase complex. | 0.944 |