STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC102121175Uncharacterized protein. (325 aa)    
Predicted Functional Partners:
DSN1
DSN1 component of MIS12 kinetochore complex.
    
 0.976
NSL1
NSL1 component of MIS12 kinetochore complex.
    
 0.968
MIS12
Uncharacterized protein.
    
 0.927
SPC24
SPC24 component of NDC80 kinetochore complex.
   
 0.912
ENSMFAP00000028463
Uncharacterized protein.
    
 0.891
NUF2
NUF2 component of NDC80 kinetochore complex.
    
 0.881
ZWINT
ZW10 interacting kinetochore protein.
    
 
 0.783
NDC80
Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spind [...]
    
 0.764
SPC25
SPC25 component of NDC80 kinetochore complex.
    
  0.746
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 0.722
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.