STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (428 aa)    
Predicted Functional Partners:
TBX21
T-box transcription factor 21.
   
 0.954
CBFB
Core-binding factor subunit beta.
    
 0.951
MYSM1
Myb like, SWIRM and MPN domains 1.
    
  0.926
ETS1
ETS proto-oncogene 1, transcription factor.
    
 0.780
CTNNB1
Catenin beta 1.
    
 0.744
YES1
Tyrosine-protein kinase.
     
 0.704
ZFHX3
Zinc finger homeobox 3.
     
 0.687
TAL1
TAL bHLH transcription factor 1, erythroid differentiation factor.
    
 0.679
EP300
E1A binding protein p300.
    
 0.677
ETS2
Protein C-ets-2; Transcription factor; Belongs to the ETS family.
    
 0.662
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.