node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADIPOQ | ADRB3 | ENSMFAP00000045575 | ENSMFAP00000044006 | Adiponectin, C1Q and collagen domain containing. | Adrenergic receptor beta 3. | 0.425 |
ADIPOQ | CIDEA | ENSMFAP00000045575 | ENSMFAP00000030642 | Adiponectin, C1Q and collagen domain containing. | Cell death inducing DFFA like effector a. | 0.460 |
ADIPOQ | FGF21 | ENSMFAP00000045575 | ENSMFAP00000017555 | Adiponectin, C1Q and collagen domain containing. | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. | 0.759 |
ADIPOQ | INS | ENSMFAP00000045575 | ENSMFAP00000009056 | Adiponectin, C1Q and collagen domain containing. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.908 |
ADIPOQ | LEP | ENSMFAP00000045575 | ENSMFAP00000024992 | Adiponectin, C1Q and collagen domain containing. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.954 |
ADIPOQ | PPARA | ENSMFAP00000045575 | ENSMFAP00000017199 | Adiponectin, C1Q and collagen domain containing. | Peroxisome proliferator activated receptor alpha. | 0.686 |
ADIPOQ | PPARG | ENSMFAP00000045575 | ENSMFAP00000035941 | Adiponectin, C1Q and collagen domain containing. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.862 |
ADIPOQ | PPARGC1A | ENSMFAP00000045575 | ENSMFAP00000045739 | Adiponectin, C1Q and collagen domain containing. | PPARG coactivator 1 alpha. | 0.638 |
ADIPOQ | UCP1 | ENSMFAP00000045575 | ENSMFAP00000024389 | Adiponectin, C1Q and collagen domain containing. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.810 |
ADRB3 | ADIPOQ | ENSMFAP00000044006 | ENSMFAP00000045575 | Adrenergic receptor beta 3. | Adiponectin, C1Q and collagen domain containing. | 0.425 |
ADRB3 | LEP | ENSMFAP00000044006 | ENSMFAP00000024992 | Adrenergic receptor beta 3. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.424 |
ADRB3 | PPARG | ENSMFAP00000044006 | ENSMFAP00000035941 | Adrenergic receptor beta 3. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.545 |
ADRB3 | UCP1 | ENSMFAP00000044006 | ENSMFAP00000024389 | Adrenergic receptor beta 3. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.758 |
CIDEA | ADIPOQ | ENSMFAP00000030642 | ENSMFAP00000045575 | Cell death inducing DFFA like effector a. | Adiponectin, C1Q and collagen domain containing. | 0.460 |
CIDEA | ELOVL3 | ENSMFAP00000030642 | ENSMFAP00000003079 | Cell death inducing DFFA like effector a. | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] | 0.651 |
CIDEA | PPARG | ENSMFAP00000030642 | ENSMFAP00000035941 | Cell death inducing DFFA like effector a. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.459 |
CIDEA | PPARGC1A | ENSMFAP00000030642 | ENSMFAP00000045739 | Cell death inducing DFFA like effector a. | PPARG coactivator 1 alpha. | 0.695 |
CIDEA | UCP1 | ENSMFAP00000030642 | ENSMFAP00000024389 | Cell death inducing DFFA like effector a. | Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.863 |
ELOVL3 | CIDEA | ENSMFAP00000003079 | ENSMFAP00000030642 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] | Cell death inducing DFFA like effector a. | 0.651 |
ELOVL3 | PPARGC1A | ENSMFAP00000003079 | ENSMFAP00000045739 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] | PPARG coactivator 1 alpha. | 0.564 |