node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BLOC1S6 | CMBL | ENSMFAP00000007211 | ENSMFAP00000003719 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | Carboxymethylenebutenolidase homolog. | 0.807 |
BLOC1S6 | KCNIP3 | ENSMFAP00000007211 | ENSMFAP00000030214 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | Potassium voltage-gated channel interacting protein 3. | 0.878 |
BLOC1S6 | PRELID3B | ENSMFAP00000007211 | ENSMFAP00000041888 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | PRELI domain containing protein 3B; Belongs to the slowmo family. | 0.818 |
BLOC1S6 | UBE2B | ENSMFAP00000007211 | ENSMFAP00000031152 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.898 |
BLOC1S6 | ZNF575 | ENSMFAP00000007211 | ENSMFAP00000027671 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | Zinc finger protein 575; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.824 |
CMBL | BLOC1S6 | ENSMFAP00000003719 | ENSMFAP00000007211 | Carboxymethylenebutenolidase homolog. | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | 0.807 |
CMBL | KCNIP3 | ENSMFAP00000003719 | ENSMFAP00000030214 | Carboxymethylenebutenolidase homolog. | Potassium voltage-gated channel interacting protein 3. | 0.870 |
CMBL | PRELID3B | ENSMFAP00000003719 | ENSMFAP00000041888 | Carboxymethylenebutenolidase homolog. | PRELI domain containing protein 3B; Belongs to the slowmo family. | 0.802 |
CMBL | UBE2B | ENSMFAP00000003719 | ENSMFAP00000031152 | Carboxymethylenebutenolidase homolog. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.898 |
CMBL | ZNF575 | ENSMFAP00000003719 | ENSMFAP00000027671 | Carboxymethylenebutenolidase homolog. | Zinc finger protein 575; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.816 |
ENSMFAP00000009791 | RAD18 | ENSMFAP00000009791 | ENSMFAP00000013554 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | RAD18 E3 ubiquitin protein ligase. | 0.701 |
ENSMFAP00000009791 | UBE2B | ENSMFAP00000009791 | ENSMFAP00000031152 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.983 |
KCNIP3 | BLOC1S6 | ENSMFAP00000030214 | ENSMFAP00000007211 | Potassium voltage-gated channel interacting protein 3. | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] | 0.878 |
KCNIP3 | CMBL | ENSMFAP00000030214 | ENSMFAP00000003719 | Potassium voltage-gated channel interacting protein 3. | Carboxymethylenebutenolidase homolog. | 0.870 |
KCNIP3 | PRELID3B | ENSMFAP00000030214 | ENSMFAP00000041888 | Potassium voltage-gated channel interacting protein 3. | PRELI domain containing protein 3B; Belongs to the slowmo family. | 0.879 |
KCNIP3 | UBE2B | ENSMFAP00000030214 | ENSMFAP00000031152 | Potassium voltage-gated channel interacting protein 3. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.877 |
KCNIP3 | ZNF575 | ENSMFAP00000030214 | ENSMFAP00000027671 | Potassium voltage-gated channel interacting protein 3. | Zinc finger protein 575; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.888 |
LEO1 | RNF20 | ENSMFAP00000018100 | ENSMFAP00000041740 | LEO1 homolog, Paf1/RNA polymerase II complex component. | E3 ubiquitin protein ligase; Belongs to the BRE1 family. | 0.968 |
LEO1 | RNF40 | ENSMFAP00000018100 | ENSMFAP00000019782 | LEO1 homolog, Paf1/RNA polymerase II complex component. | E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] | 0.967 |
LEO1 | UBE2B | ENSMFAP00000018100 | ENSMFAP00000031152 | LEO1 homolog, Paf1/RNA polymerase II complex component. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.950 |