node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDI1 | NRIP3 | ENSMFAP00000013518 | ENSMFAP00000032933 | Protein DDI1 homolog 1; Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity). | Nuclear receptor interacting protein 3. | 0.552 |
DDI1 | RAD23A | ENSMFAP00000013518 | ENSMFAP00000033839 | Protein DDI1 homolog 1; Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity). | RAD23 homolog A, nucleotide excision repair protein. | 0.494 |
ENSMFAP00000009883 | NRIP3 | ENSMFAP00000009883 | ENSMFAP00000032933 | Ubiquitin-like domain-containing protein. | Nuclear receptor interacting protein 3. | 0.433 |
ENSMFAP00000009883 | PSMD2 | ENSMFAP00000009883 | ENSMFAP00000037682 | Ubiquitin-like domain-containing protein. | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. | 0.830 |
ENSMFAP00000009883 | PSMD4 | ENSMFAP00000009883 | ENSMFAP00000045865 | Ubiquitin-like domain-containing protein. | Proteasome 26S subunit, non-ATPase 4. | 0.851 |
ENSMFAP00000009883 | RAD23A | ENSMFAP00000009883 | ENSMFAP00000033839 | Ubiquitin-like domain-containing protein. | RAD23 homolog A, nucleotide excision repair protein. | 0.739 |
ENSMFAP00000009883 | RAD23B | ENSMFAP00000009883 | ENSMFAP00000017697 | Ubiquitin-like domain-containing protein. | Uncharacterized protein. | 0.651 |
KCNJ6 | NRIP3 | ENSMFAP00000044782 | ENSMFAP00000032933 | Potassium voltage-gated channel subfamily J member 6. | Nuclear receptor interacting protein 3. | 0.616 |
KCNJ6 | ZDHHC2 | ENSMFAP00000044782 | ENSMFAP00000031636 | Potassium voltage-gated channel subfamily J member 6. | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. | 0.614 |
NDNF | NRIP3 | ENSMFAP00000033951 | ENSMFAP00000032933 | Neuron derived neurotrophic factor. | Nuclear receptor interacting protein 3. | 0.616 |
NDNF | ZDHHC2 | ENSMFAP00000033951 | ENSMFAP00000031636 | Neuron derived neurotrophic factor. | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. | 0.615 |
NRIP3 | DDI1 | ENSMFAP00000032933 | ENSMFAP00000013518 | Nuclear receptor interacting protein 3. | Protein DDI1 homolog 1; Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity). | 0.552 |
NRIP3 | ENSMFAP00000009883 | ENSMFAP00000032933 | ENSMFAP00000009883 | Nuclear receptor interacting protein 3. | Ubiquitin-like domain-containing protein. | 0.433 |
NRIP3 | KCNJ6 | ENSMFAP00000032933 | ENSMFAP00000044782 | Nuclear receptor interacting protein 3. | Potassium voltage-gated channel subfamily J member 6. | 0.616 |
NRIP3 | NDNF | ENSMFAP00000032933 | ENSMFAP00000033951 | Nuclear receptor interacting protein 3. | Neuron derived neurotrophic factor. | 0.616 |
NRIP3 | PSMD2 | ENSMFAP00000032933 | ENSMFAP00000037682 | Nuclear receptor interacting protein 3. | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. | 0.504 |
NRIP3 | PSMD4 | ENSMFAP00000032933 | ENSMFAP00000045865 | Nuclear receptor interacting protein 3. | Proteasome 26S subunit, non-ATPase 4. | 0.496 |
NRIP3 | RAD23A | ENSMFAP00000032933 | ENSMFAP00000033839 | Nuclear receptor interacting protein 3. | RAD23 homolog A, nucleotide excision repair protein. | 0.596 |
NRIP3 | RAD23B | ENSMFAP00000032933 | ENSMFAP00000017697 | Nuclear receptor interacting protein 3. | Uncharacterized protein. | 0.596 |
NRIP3 | TBC1D30 | ENSMFAP00000032933 | ENSMFAP00000039670 | Nuclear receptor interacting protein 3. | TBC1 domain family member 30. | 0.552 |