node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKEF1 | CCDC65 | ENSMFAP00000032763 | ENSMFAP00000045929 | Ankyrin repeat and EF-hand domain containing 1. | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | 0.592 |
ANKEF1 | CFAP99 | ENSMFAP00000032763 | ENSMFAP00000035768 | Ankyrin repeat and EF-hand domain containing 1. | Cilia and flagella associated protein 99. | 0.628 |
ANKEF1 | DNAH10 | ENSMFAP00000032763 | ENSMFAP00000033135 | Ankyrin repeat and EF-hand domain containing 1. | Dynein axonemal heavy chain 10. | 0.627 |
ANKEF1 | RSPH4A | ENSMFAP00000032763 | ENSMFAP00000039085 | Ankyrin repeat and EF-hand domain containing 1. | Radial spoke head component 4A. | 0.576 |
ANKEF1 | RSPH6A | ENSMFAP00000032763 | ENSMFAP00000013559 | Ankyrin repeat and EF-hand domain containing 1. | Radial spoke head 6 homolog A. | 0.576 |
CCDC65 | ANKEF1 | ENSMFAP00000045929 | ENSMFAP00000032763 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | Ankyrin repeat and EF-hand domain containing 1. | 0.592 |
CCDC65 | CFAP99 | ENSMFAP00000045929 | ENSMFAP00000035768 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | Cilia and flagella associated protein 99. | 0.625 |
CCDC65 | DNAH10 | ENSMFAP00000045929 | ENSMFAP00000033135 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | Dynein axonemal heavy chain 10. | 0.658 |
CCDC65 | PANK4 | ENSMFAP00000045929 | ENSMFAP00000009013 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | 4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their co [...] | 0.437 |
CCDC65 | RSPH4A | ENSMFAP00000045929 | ENSMFAP00000039085 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | Radial spoke head component 4A. | 0.707 |
CCDC65 | RSPH6A | ENSMFAP00000045929 | ENSMFAP00000013559 | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | Radial spoke head 6 homolog A. | 0.708 |
CFAP99 | ANKEF1 | ENSMFAP00000035768 | ENSMFAP00000032763 | Cilia and flagella associated protein 99. | Ankyrin repeat and EF-hand domain containing 1. | 0.628 |
CFAP99 | CCDC65 | ENSMFAP00000035768 | ENSMFAP00000045929 | Cilia and flagella associated protein 99. | Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. | 0.625 |
CFAP99 | DNAH10 | ENSMFAP00000035768 | ENSMFAP00000033135 | Cilia and flagella associated protein 99. | Dynein axonemal heavy chain 10. | 0.616 |
CFAP99 | FARP2 | ENSMFAP00000035768 | ENSMFAP00000025191 | Cilia and flagella associated protein 99. | FERM, ARH/RhoGEF and pleckstrin domain protein 2. | 0.524 |
CFAP99 | LRGUK | ENSMFAP00000035768 | ENSMFAP00000043135 | Cilia and flagella associated protein 99. | Leucine rich repeats and guanylate kinase domain containing. | 0.566 |
CFAP99 | PANK4 | ENSMFAP00000035768 | ENSMFAP00000009013 | Cilia and flagella associated protein 99. | 4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their co [...] | 0.453 |
CFAP99 | RSPH4A | ENSMFAP00000035768 | ENSMFAP00000039085 | Cilia and flagella associated protein 99. | Radial spoke head component 4A. | 0.554 |
CFAP99 | RSPH6A | ENSMFAP00000035768 | ENSMFAP00000013559 | Cilia and flagella associated protein 99. | Radial spoke head 6 homolog A. | 0.560 |
CFAP99 | SSNA1 | ENSMFAP00000035768 | ENSMFAP00000033833 | Cilia and flagella associated protein 99. | SS nuclear autoantigen 1. | 0.468 |