node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSMFAP00000036233 | GTF2A1 | ENSMFAP00000036233 | ENSMFAP00000000529 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | General transcription factor IIA subunit 1. | 0.949 |
ENSMFAP00000036233 | GTF2B | ENSMFAP00000036233 | ENSMFAP00000009527 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | Transcription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II- TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter [...] | 0.924 |
ENSMFAP00000036233 | GTF2E1 | ENSMFAP00000036233 | ENSMFAP00000005745 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | General transcription factor IIE subunit 1. | 0.918 |
ENSMFAP00000036233 | GTF2E2 | ENSMFAP00000036233 | ENSMFAP00000017036 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.925 |
ENSMFAP00000036233 | GTF2F1 | ENSMFAP00000036233 | ENSMFAP00000033760 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. | 0.917 |
ENSMFAP00000036233 | GTF2F2 | ENSMFAP00000036233 | ENSMFAP00000011647 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. | 0.896 |
ENSMFAP00000036233 | GTF2H2 | ENSMFAP00000036233 | ENSMFAP00000008107 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | General transcription factor IIH subunit. | 0.913 |
ENSMFAP00000036233 | POLR2B | ENSMFAP00000036233 | ENSMFAP00000030145 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.897 |
ENSMFAP00000036233 | POLR2H | ENSMFAP00000036233 | ENSMFAP00000037786 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. | 0.902 |
ENSMFAP00000036233 | TBP | ENSMFAP00000036233 | ENSMFAP00000015908 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] | 0.926 |
GTF2A1 | ENSMFAP00000036233 | ENSMFAP00000000529 | ENSMFAP00000036233 | General transcription factor IIA subunit 1. | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. | 0.949 |
GTF2A1 | GTF2B | ENSMFAP00000000529 | ENSMFAP00000009527 | General transcription factor IIA subunit 1. | Transcription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II- TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter [...] | 0.983 |
GTF2A1 | GTF2E1 | ENSMFAP00000000529 | ENSMFAP00000005745 | General transcription factor IIA subunit 1. | General transcription factor IIE subunit 1. | 0.982 |
GTF2A1 | GTF2E2 | ENSMFAP00000000529 | ENSMFAP00000017036 | General transcription factor IIA subunit 1. | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. | 0.964 |
GTF2A1 | GTF2F1 | ENSMFAP00000000529 | ENSMFAP00000033760 | General transcription factor IIA subunit 1. | Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. | 0.951 |
GTF2A1 | GTF2F2 | ENSMFAP00000000529 | ENSMFAP00000011647 | General transcription factor IIA subunit 1. | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. | 0.982 |
GTF2A1 | GTF2H2 | ENSMFAP00000000529 | ENSMFAP00000008107 | General transcription factor IIA subunit 1. | General transcription factor IIH subunit. | 0.978 |
GTF2A1 | POLR2B | ENSMFAP00000000529 | ENSMFAP00000030145 | General transcription factor IIA subunit 1. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.956 |
GTF2A1 | POLR2H | ENSMFAP00000000529 | ENSMFAP00000037786 | General transcription factor IIA subunit 1. | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. | 0.956 |
GTF2A1 | TBP | ENSMFAP00000000529 | ENSMFAP00000015908 | General transcription factor IIA subunit 1. | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase [...] | 0.990 |