STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACY3Aminoacylase 3. (319 aa)    
Predicted Functional Partners:
DHRS9
Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.640
ENSMFAP00000030335
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.569
ENSMFAP00000031351
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.569
SKP1
S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]
    
 0.569
CACUL1
CDK2 associated cullin domain 1; Belongs to the cullin family.
    
 0.540
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.540
CUL1
Cullin 1; Belongs to the cullin family.
    
 0.540
TRIP12
Thyroid hormone receptor interactor 12.
   
 0.539
TCL1A
T cell leukemia/lymphoma 1A.
      
 0.522
RNF7
Ring finger protein 7.
    
 0.515
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.