STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. (329 aa)    
Predicted Functional Partners:
BID
BH3 interacting domain death agonist.
     
 0.909
BCL2
BCL2 apoptosis regulator.
     
 0.908
BCL2L1
BCL2 like 1.
     
 0.904
SERPINB13
Serpin family B member 13; Belongs to the serpin family.
    
 0.701
CSTA
Cystatin A; Belongs to the cystatin family.
   
 0.697
MMP13
Matrix metallopeptidase 13.
   
 
 0.672
BIRC2
Baculoviral IAP repeat containing 2.
   
 
 0.669
BIRC3
Baculoviral IAP repeat containing 3.
   
 
 0.669
XIAP
X-linked inhibitor of apoptosis.
     
 0.661
BIRC5-2
Uncharacterized protein.
     
 0.659
Your Current Organism:
Macaca fascicularis
NCBI taxonomy Id: 9541
Other names: M. fascicularis, Macaca cynomolgus, Macaca irus, crab eating macaque, crab-eating macaque, cynomolgus macaque, cynomolgus monkey, cynomolgus monkeys, long-tailed macaque
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.