STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIM22E3 ubiquitin-protein ligase TRIM22 isoform 1. (498 aa)    
Predicted Functional Partners:
BBOX1
Gamma-butyrobetaine hydroxylase 1.
      
 0.740
APOBEC3H
DNA dC->dU-editing enzyme APOBEC-3H; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels [...]
   
  
 0.731
APOBEC3D
DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient: HIV-1 and simian immunodeficiency viruses (SIVs). After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single- strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-stran [...]
   
  
 0.648
ISG15
Ubiquitin-like protein ISG15.
   
 0.632
TRAT1
T cell receptor associated transmembrane adaptor 1.
      
 0.626
TLR4
Toll like receptor 4; Belongs to the Toll-like receptor family.
   
 
 0.618
IFIT3
Interferon induced protein with tetratricopeptide repeats 3.
   
 0.599
MNDA
Gamma-interferon-inducible protein 16 isoform 2.
   
 0.588
MX2
Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with antiviral activity.
   
 
 0.576
MX1
Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity.
   
 
 0.574
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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