node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EPAS1 | HIF1A | ENSMMUP00000054188 | ENSMMUP00000056541 | Endothelial PAS domain protein 1. | Hypoxia-inducible factor 1-alpha isoform 1. | 0.986 |
EPAS1 | SLC2A1 | ENSMMUP00000054188 | ENSMMUP00000054322 | Endothelial PAS domain protein 1. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.609 |
EPAS1 | TP53 | ENSMMUP00000054188 | ENSMMUP00000011334 | Endothelial PAS domain protein 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.576 |
HIF1A | EPAS1 | ENSMMUP00000056541 | ENSMMUP00000054188 | Hypoxia-inducible factor 1-alpha isoform 1. | Endothelial PAS domain protein 1. | 0.986 |
HIF1A | INS | ENSMMUP00000056541 | ENSMMUP00000037777 | Hypoxia-inducible factor 1-alpha isoform 1. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.470 |
HIF1A | SLC2A1 | ENSMMUP00000056541 | ENSMMUP00000054322 | Hypoxia-inducible factor 1-alpha isoform 1. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.628 |
HIF1A | TP53 | ENSMMUP00000056541 | ENSMMUP00000011334 | Hypoxia-inducible factor 1-alpha isoform 1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.907 |
INS | HIF1A | ENSMMUP00000037777 | ENSMMUP00000056541 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Hypoxia-inducible factor 1-alpha isoform 1. | 0.470 |
INS | SLC1A5 | ENSMMUP00000037777 | ENSMMUP00000080583 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Amino acid transporter. | 0.469 |
INS | SLC2A1 | ENSMMUP00000037777 | ENSMMUP00000054322 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.575 |
INS | SLC2A2 | ENSMMUP00000037777 | ENSMMUP00000038697 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.602 |
INS | SLC2A4 | ENSMMUP00000037777 | ENSMMUP00000035308 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.710 |
INS | TP53 | ENSMMUP00000037777 | ENSMMUP00000011334 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.704 |
SEC13 | SLC2A1 | ENSMMUP00000026199 | ENSMMUP00000054322 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.735 |
SLC1A3 | SLC2A1 | ENSMMUP00000008151 | ENSMMUP00000054322 | Amino acid transporter. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.630 |
SLC1A5 | INS | ENSMMUP00000080583 | ENSMMUP00000037777 | Amino acid transporter. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.469 |
SLC1A5 | SLC2A1 | ENSMMUP00000080583 | ENSMMUP00000054322 | Amino acid transporter. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.656 |
SLC1A7 | SLC2A1 | ENSMMUP00000009985 | ENSMMUP00000054322 | Amino acid transporter. | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | 0.582 |
SLC2A1 | EPAS1 | ENSMMUP00000054322 | ENSMMUP00000054188 | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Endothelial PAS domain protein 1. | 0.609 |
SLC2A1 | HIF1A | ENSMMUP00000054322 | ENSMMUP00000056541 | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. | Hypoxia-inducible factor 1-alpha isoform 1. | 0.628 |