STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCN8ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1980 aa)    
Predicted Functional Partners:
UNC79
Unc-79 homolog, NALCN channel complex subunit.
   
 0.974
SCN1B
Sodium voltage-gated channel beta subunit 1.
   
 0.935
SCN2B
Sodium voltage-gated channel beta subunit 2.
   
 0.889
SCN4B
Sodium voltage-gated channel beta subunit 4.
    
 0.884
SCN3B
Ig-like domain-containing protein.
   
 0.808
PDLIM3
PDZ and LIM domain 3.
      
 0.807
DIS3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family.
   
  
 0.777
KCNC2
Potassium voltage-gated channel subfamily C member 2 isoform KV3.2b; Belongs to the potassium channel family.
   
 
 0.720
CLCN2
Chloride channel protein.
   
  
 0.711
CCKBR
Cholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family.
   
 
 0.711
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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