NPC1L1 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

NPC1L1

SSD domain-containing protein. (1363 aa)

Predicted Functional Partners:

NPC2

0.932

ABCG5

0.879

ABCG8

0.861

SREBF1

0.818

CLDN1

0.809

SREBF2

0.807

PAK1IP1

0.778

ABCA1

0.768

HMGCR

0.765

EPHA2

0.760

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCA1	ABCG5	ENSMMUP00000061741	ENSMMUP00000010587	ATP binding cassette subfamily A member 1.	ATP binding cassette subfamily G member 5.	0.441
ABCA1	HMGCR	ENSMMUP00000061741	ENSMMUP00000008068	ATP binding cassette subfamily A member 1.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.751
ABCA1	NPC1L1	ENSMMUP00000061741	ENSMMUP00000001055	ATP binding cassette subfamily A member 1.	SSD domain-containing protein.	0.768
ABCA1	SREBF1	ENSMMUP00000061741	ENSMMUP00000052484	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 1.	0.699
ABCA1	SREBF2	ENSMMUP00000061741	ENSMMUP00000004473	ATP binding cassette subfamily A member 1.	Sterol regulatory element binding transcription factor 2.	0.795
ABCG5	ABCA1	ENSMMUP00000010587	ENSMMUP00000061741	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily A member 1.	0.441
ABCG5	ABCG8	ENSMMUP00000010587	ENSMMUP00000071755	ATP binding cassette subfamily G member 5.	ATP binding cassette subfamily G member 8.	0.999
ABCG5	HMGCR	ENSMMUP00000010587	ENSMMUP00000008068	ATP binding cassette subfamily G member 5.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.682
ABCG5	NPC1L1	ENSMMUP00000010587	ENSMMUP00000001055	ATP binding cassette subfamily G member 5.	SSD domain-containing protein.	0.879
ABCG5	SREBF1	ENSMMUP00000010587	ENSMMUP00000052484	ATP binding cassette subfamily G member 5.	Sterol regulatory element binding transcription factor 1.	0.477
ABCG5	SREBF2	ENSMMUP00000010587	ENSMMUP00000004473	ATP binding cassette subfamily G member 5.	Sterol regulatory element binding transcription factor 2.	0.531
ABCG8	ABCG5	ENSMMUP00000071755	ENSMMUP00000010587	ATP binding cassette subfamily G member 8.	ATP binding cassette subfamily G member 5.	0.999
ABCG8	HMGCR	ENSMMUP00000071755	ENSMMUP00000008068	ATP binding cassette subfamily G member 8.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.750
ABCG8	NPC1L1	ENSMMUP00000071755	ENSMMUP00000001055	ATP binding cassette subfamily G member 8.	SSD domain-containing protein.	0.861
ABCG8	SREBF1	ENSMMUP00000071755	ENSMMUP00000052484	ATP binding cassette subfamily G member 8.	Sterol regulatory element binding transcription factor 1.	0.423
ABCG8	SREBF2	ENSMMUP00000071755	ENSMMUP00000004473	ATP binding cassette subfamily G member 8.	Sterol regulatory element binding transcription factor 2.	0.511
CLDN1	EPHA2	ENSMMUP00000002562	ENSMMUP00000079185	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	EPH receptor A2.	0.697
CLDN1	NPC1L1	ENSMMUP00000002562	ENSMMUP00000001055	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	SSD domain-containing protein.	0.809
EPHA2	CLDN1	ENSMMUP00000079185	ENSMMUP00000002562	EPH receptor A2.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.697
EPHA2	NPC1L1	ENSMMUP00000079185	ENSMMUP00000001055	EPH receptor A2.	SSD domain-containing protein.	0.760