Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MSH4MutS homolog 4. (935 aa)    
Predicted Functional Partners:
MSH5
DNA_MISMATCH_REPAIR_2 domain-containing protein.
  
0.990
MLH3
Uncharacterized protein.
  
 0.908
MLH1
MutL homolog 1.
 
 0.902
PMS1
PMS1 homolog 1, mismatch repair system component.
 
 0.872
SPO11
SPO11 initiator of meiotic double stranded breaks.
   
 
 0.867
PMS2
PMS1 homolog 2, mismatch repair system component.
 
 0.841
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
   
 
 0.835
SHOC1
Uncharacterized protein.
      
 0.805
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.796
RNF212B
Ring finger protein 212B.
   
 
 0.796
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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