Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
REXO4REX4 homolog, 3'-5' exonuclease. (422 aa)    
Predicted Functional Partners:
RBM34
RNA binding motif protein 34.
   
 0.901
DEDD
DED domain-containing protein.
      
 0.870
RRP8
Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]
   
   0.846
RBM28
RNA binding motif protein 28.
   
 
 0.819
PPAN
PPAN-P2RY11 readthrough; Belongs to the G-protein coupled receptor 1 family.
   
   0.810
CEBPZ
CCAAT enhancer binding protein zeta.
   
 
 0.798
DDX55
RNA helicase.
   
 0.790
WDR18
WD repeat domain 18.
   
  0.775
RPL8
60S ribosomal protein L8.
   
  0.771
WDR46
WD repeat domain 46.
   
   0.771
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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