node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL11 | CCL13 | ENSMMUP00000070332 | ENSMMUP00000012809 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine. | 0.993 |
CCL11 | CCL15 | ENSMMUP00000070332 | ENSMMUP00000003319 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine. | 0.941 |
CCL11 | CCL23 | ENSMMUP00000070332 | ENSMMUP00000080372 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine 23; Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | 0.942 |
CCL11 | CCL26 | ENSMMUP00000070332 | ENSMMUP00000020657 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine. | 0.993 |
CCL11 | CCL27 | ENSMMUP00000070332 | ENSMMUP00000027364 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | Small-inducible cytokine A27. | 0.994 |
CCL11 | CCL5 | ENSMMUP00000070332 | ENSMMUP00000073204 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.993 |
CCL11 | CCL7 | ENSMMUP00000070332 | ENSMMUP00000012803 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine. | 0.913 |
CCL11 | CCR1 | ENSMMUP00000070332 | ENSMMUP00000072210 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. | 0.918 |
CCL11 | CCR3 | ENSMMUP00000070332 | ENSMMUP00000006084 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.997 |
CCL13 | CCL11 | ENSMMUP00000012809 | ENSMMUP00000070332 | C-C motif chemokine. | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | 0.993 |
CCL13 | CCL15 | ENSMMUP00000012809 | ENSMMUP00000003319 | C-C motif chemokine. | C-C motif chemokine. | 0.931 |
CCL13 | CCL21 | ENSMMUP00000012809 | ENSMMUP00000070168 | C-C motif chemokine. | C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity). | 0.947 |
CCL13 | CCL23 | ENSMMUP00000012809 | ENSMMUP00000080372 | C-C motif chemokine. | C-C motif chemokine 23; Shows chemotactic activity for monocytes, resting T- lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | 0.952 |
CCL13 | CCL26 | ENSMMUP00000012809 | ENSMMUP00000020657 | C-C motif chemokine. | C-C motif chemokine. | 0.992 |
CCL13 | CCL27 | ENSMMUP00000012809 | ENSMMUP00000027364 | C-C motif chemokine. | Small-inducible cytokine A27. | 0.953 |
CCL13 | CCL5 | ENSMMUP00000012809 | ENSMMUP00000073204 | C-C motif chemokine. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.994 |
CCL13 | CCL7 | ENSMMUP00000012809 | ENSMMUP00000012803 | C-C motif chemokine. | C-C motif chemokine. | 0.914 |
CCL13 | CCR1 | ENSMMUP00000012809 | ENSMMUP00000072210 | C-C motif chemokine. | C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, MCP-3 and, less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. | 0.976 |
CCL13 | CCR3 | ENSMMUP00000012809 | ENSMMUP00000006084 | C-C motif chemokine. | C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. | 0.973 |
CCL15 | CCL11 | ENSMMUP00000003319 | ENSMMUP00000070332 | C-C motif chemokine. | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. | 0.941 |