CYP11B2 protein (Macaca mulatta) - STRING interaction network

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Score

CYP11B2

Uncharacterized protein; Belongs to the cytochrome P450 family. (503 aa)

Predicted Functional Partners:

HSD3B2

0.969

HSD11B2

0.960

CYP21A2

0.958

CYP17A1

0.958

HSD3B1

0.943

HSD17B3

0.940

HSD11B1

0.935

SRD5A1

0.934

AKR1C1

0.933

CYP19A1

0.932

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1C1	CYP11B2	ENSMMUP00000047543	ENSMMUP00000001289	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.933
AKR1C1	CYP17A1	ENSMMUP00000047543	ENSMMUP00000061406	Aldo_ket_red domain-containing protein.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.945
AKR1C1	CYP19A1	ENSMMUP00000047543	ENSMMUP00000053305	Aldo_ket_red domain-containing protein.	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	0.929
AKR1C1	HSD17B3	ENSMMUP00000047543	ENSMMUP00000038724	Aldo_ket_red domain-containing protein.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.952
AKR1C1	HSD3B1	ENSMMUP00000047543	ENSMMUP00000015345	Aldo_ket_red domain-containing protein.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; Belongs to the 3-beta-HSD family.	0.940
AKR1C1	HSD3B2	ENSMMUP00000047543	ENSMMUP00000077828	Aldo_ket_red domain-containing protein.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controllin [...]	0.951
AKR1C1	SRD5A1	ENSMMUP00000047543	ENSMMUP00000017322	Aldo_ket_red domain-containing protein.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.948
CYP11B2	AKR1C1	ENSMMUP00000001289	ENSMMUP00000047543	Uncharacterized protein; Belongs to the cytochrome P450 family.	Aldo_ket_red domain-containing protein.	0.933
CYP11B2	CYP17A1	ENSMMUP00000001289	ENSMMUP00000061406	Uncharacterized protein; Belongs to the cytochrome P450 family.	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	0.958
CYP11B2	CYP19A1	ENSMMUP00000001289	ENSMMUP00000053305	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	0.932
CYP11B2	CYP21A2	ENSMMUP00000001289	ENSMMUP00000001019	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.958
CYP11B2	HSD11B1	ENSMMUP00000001289	ENSMMUP00000080914	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.935
CYP11B2	HSD11B2	ENSMMUP00000001289	ENSMMUP00000010536	Uncharacterized protein; Belongs to the cytochrome P450 family.	Hydroxysteroid 11-beta dehydrogenase 2.	0.960
CYP11B2	HSD17B3	ENSMMUP00000001289	ENSMMUP00000038724	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.940
CYP11B2	HSD3B1	ENSMMUP00000001289	ENSMMUP00000015345	Uncharacterized protein; Belongs to the cytochrome P450 family.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; Belongs to the 3-beta-HSD family.	0.943
CYP11B2	HSD3B2	ENSMMUP00000001289	ENSMMUP00000077828	Uncharacterized protein; Belongs to the cytochrome P450 family.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controllin [...]	0.969
CYP11B2	SRD5A1	ENSMMUP00000001289	ENSMMUP00000017322	Uncharacterized protein; Belongs to the cytochrome P450 family.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.934
CYP17A1	AKR1C1	ENSMMUP00000061406	ENSMMUP00000047543	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Aldo_ket_red domain-containing protein.	0.945
CYP17A1	CYP11B2	ENSMMUP00000061406	ENSMMUP00000001289	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.958
CYP17A1	CYP19A1	ENSMMUP00000061406	ENSMMUP00000053305	Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...]	Cytochrome P450 19A1; Belongs to the cytochrome P450 family.	0.961