Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (309 aa)    
Predicted Functional Partners:
IRAK4
Interleukin-1 receptor-associated kinase 4.
   
 0.999
TRAF6
TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...]
   
 0.999
IRAK1
Interleukin 1 receptor associated kinase 1.
   
 0.999
IL1R1
Interleukin 1 receptor type 1.
    
 0.998
TLR4
Toll like receptor 4; Belongs to the Toll-like receptor family.
   
0.997
TLR7
Toll-like receptor 7; Belongs to the Toll-like receptor family.
    
 0.996
TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein isoform a.
   
0.996
IRAK2
Interleukin 1 receptor associated kinase 2.
   
 0.995
TLR5
Toll like receptor 5; Belongs to the Toll-like receptor family.
   
 0.994
TLR6
Toll-like receptor.
   
 0.994
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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