node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IRAK1 | IRAK4 | ENSMMUP00000024614 | ENSMMUP00000000286 | Interleukin 1 receptor associated kinase 1. | Interleukin-1 receptor-associated kinase 4. | 0.999 |
IRAK1 | LY96 | ENSMMUP00000024614 | ENSMMUP00000004030 | Interleukin 1 receptor associated kinase 1. | MD2 protein. | 0.716 |
IRAK1 | MAP3K7 | ENSMMUP00000024614 | ENSMMUP00000033340 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7. | 0.974 |
IRAK1 | MYD88 | ENSMMUP00000024614 | ENSMMUP00000001339 | Interleukin 1 receptor associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.999 |
IRAK1 | TIRAP | ENSMMUP00000024614 | ENSMMUP00000070519 | Interleukin 1 receptor associated kinase 1. | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. | 0.987 |
IRAK1 | TLR4 | ENSMMUP00000024614 | ENSMMUP00000039787 | Interleukin 1 receptor associated kinase 1. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.897 |
IRAK1 | TLR5 | ENSMMUP00000024614 | ENSMMUP00000001163 | Interleukin 1 receptor associated kinase 1. | Toll like receptor 5; Belongs to the Toll-like receptor family. | 0.736 |
IRAK1 | TLR7 | ENSMMUP00000024614 | ENSMMUP00000018719 | Interleukin 1 receptor associated kinase 1. | Toll-like receptor 7; Belongs to the Toll-like receptor family. | 0.850 |
IRAK1 | TLR8 | ENSMMUP00000024614 | ENSMMUP00000018720 | Interleukin 1 receptor associated kinase 1. | Toll-like receptor 8; Belongs to the Toll-like receptor family. | 0.727 |
IRAK1 | TRAF6 | ENSMMUP00000024614 | ENSMMUP00000024012 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.999 |
IRAK4 | IRAK1 | ENSMMUP00000000286 | ENSMMUP00000024614 | Interleukin-1 receptor-associated kinase 4. | Interleukin 1 receptor associated kinase 1. | 0.999 |
IRAK4 | LY96 | ENSMMUP00000000286 | ENSMMUP00000004030 | Interleukin-1 receptor-associated kinase 4. | MD2 protein. | 0.517 |
IRAK4 | MAP3K7 | ENSMMUP00000000286 | ENSMMUP00000033340 | Interleukin-1 receptor-associated kinase 4. | Mitogen-activated protein kinase kinase kinase 7. | 0.928 |
IRAK4 | MYD88 | ENSMMUP00000000286 | ENSMMUP00000001339 | Interleukin-1 receptor-associated kinase 4. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.999 |
IRAK4 | TIRAP | ENSMMUP00000000286 | ENSMMUP00000070519 | Interleukin-1 receptor-associated kinase 4. | Toll/interleukin-1 receptor domain-containing adapter protein isoform a. | 0.983 |
IRAK4 | TLR4 | ENSMMUP00000000286 | ENSMMUP00000039787 | Interleukin-1 receptor-associated kinase 4. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.985 |
IRAK4 | TLR5 | ENSMMUP00000000286 | ENSMMUP00000001163 | Interleukin-1 receptor-associated kinase 4. | Toll like receptor 5; Belongs to the Toll-like receptor family. | 0.662 |
IRAK4 | TLR7 | ENSMMUP00000000286 | ENSMMUP00000018719 | Interleukin-1 receptor-associated kinase 4. | Toll-like receptor 7; Belongs to the Toll-like receptor family. | 0.811 |
IRAK4 | TLR8 | ENSMMUP00000000286 | ENSMMUP00000018720 | Interleukin-1 receptor-associated kinase 4. | Toll-like receptor 8; Belongs to the Toll-like receptor family. | 0.755 |
IRAK4 | TRAF6 | ENSMMUP00000000286 | ENSMMUP00000024012 | Interleukin-1 receptor-associated kinase 4. | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] | 0.999 |