Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
F7Coagulation factor VII. (526 aa)    
Predicted Functional Partners:
F3
Tissue factor isoform 1.
    
 0.997
F10
Coagulation factor X.
   
 0.950
TFPI
Tissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
    
 0.950
GGCX
Vitamin K-dependent gamma-carboxylase isoform 1.
    
 0.932
F8
Coagulation factor VIII; Belongs to the multicopper oxidase family.
   
 0.884
SERPINC1
Antithrombin III; Belongs to the serpin family.
   
 0.855
PROCR
Protein C receptor.
    
 0.828
F9
Coagulation factor IX.
   
 0.799
THBD
Uncharacterized protein.
    
 0.794
F2
Coagulation factor II, thrombin; Belongs to the peptidase S1 family.
  
0.781
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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