Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PTCHD1Patched domain containing 1. (888 aa)    
Predicted Functional Partners:
HERC1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.
      
 0.672
DLG4
Uncharacterized protein; Belongs to the MAGUK family.
    
 
 0.654
SHANK2
SH3 and multiple ankyrin repeat domains 2.
      
 0.652
DLGAP2
DLG associated protein 2.
   
  
 0.647
DDX53
DEAD-box helicase 53; Belongs to the DEAD box helicase family.
      
 0.610
PBDC1
Polysaccharide biosynthesis domain containing 1.
      
 0.602
NLGN3
Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity).
      
 0.597
DLG3
Uncharacterized protein; Belongs to the MAGUK family.
    
 
 0.587
TLX2
T cell leukemia homeobox 2.
    
 
 0.586
SHANK3
SH3 and multiple ankyrin repeat domains 3.
      
 0.582
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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