Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DACT1Dishevelled binding antagonist of beta catenin 1. (837 aa)    
Predicted Functional Partners:
DVL2
Dishevelled segment polarity protein 2.
    
 0.967
DVL3
Segment polarity protein dishevelled homolog DVL-3.
    
 0.940
DVL1
Dishevelled segment polarity protein 1.
    
 0.929
SESTD1
SEC14 domain and spectrin repeat-containing protein 1.
    
 
 0.855
VANGL2
Vang-like protein.
    
 
 0.799
VANGL1
Vang-like protein.
    
 
 0.730
HDAC1
Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
    
 
 0.705
CTNNB1
Catenin beta-1.
    
 0.673
KIAA0586
KIAA0586.
      
 0.659
SHISA3
Shisa family member 3.
      
 0.568
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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