Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TICRRTOPBP1 interacting checkpoint and replication regulator. (1909 aa)    
Predicted Functional Partners:
TOPBP1
Uncharacterized protein.
   
 
 0.982
CDC45
Cell division cycle 45.
   
  
 0.895
CCNA2
Cyclin-A2; Belongs to the cyclin family.
   
 0.883
CCNA1
Cyclin-A1 isoform a; Belongs to the cyclin family.
   
 0.879
MTBP
MDM2 binding protein.
   
 0.865
DBF4
Protein DBF4 homolog A.
   
  
 0.821
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.814
BUB1
BUB1 mitotic checkpoint serine/threonine kinase.
   
 
 0.742
MKI67
Marker of proliferation Ki-67.
   
 
 0.736
EXO1
Exonuclease 1.
  
 0.708
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.