Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TP53I3PKS_ER domain-containing protein. (346 aa)    
Predicted Functional Partners:
EI24
EI24 autophagy associated transmembrane protein.
     
 0.904
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.781
AATK
Apoptosis associated tyrosine kinase.
      
 0.753
MYADM
Myeloid-associated differentiation marker.
      
 0.677
TP53I11
Uncharacterized protein.
      
 0.647
TTC37
Tetratricopeptide repeat domain 37.
      
 0.637
HSDL2
Hydroxysteroid dehydrogenase-like protein 2 isoform 1.
  
 0.598
SESN1
Sestrin 1.
      
 0.569
FDXR
NADPH:adrenodoxin oxidoreductase, mitochondrial.
      
 0.564
MMUT
Methylmalonyl-CoA mutase.
    
   0.563
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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