STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity). (677 aa)    
Predicted Functional Partners:
JAK2
Tyrosine-protein kinase.
    
 0.993
CSH4
Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family.
   
 0.991
GH1
Uncharacterized protein.
   
 0.990
LOC114673168
Uncharacterized protein.
    
 0.988
CSH2
Uncharacterized protein.
    
 0.988
PRL
Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.
   
 
 0.947
JAK3
Janus kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family.
    
 0.943
JAK1
Tyrosine-protein kinase.
   
 0.917
IGF1
Insulin like growth factor 1.
   
  
 0.875
LOC718474
Growth hormone variant; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.
    
 0.863
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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