Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KIR3DL3Uncharacterized protein. (475 aa)    
Predicted Functional Partners:
HLA-E
Major histocompatibility complex, class I, E; Belongs to the MHC class I family.
    
 0.904
LOC106995452
Ig-like domain-containing protein; Belongs to the MHC class I family.
    
 0.801
ENSMMUP00000076171
Ig-like domain-containing protein; Belongs to the MHC class I family.
    
 0.793
LOC720132
Major histocompatibility complex, class I, AG; Belongs to the MHC class I family.
    
 0.734
LOC100426197
Ig-like domain-containing protein.
    
  0.719
MAMU-F
Mamu class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system.
    
 0.718
ENSMMUP00000053186
IGc1 domain-containing protein.
    
  0.682
TYROBP
TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]
   
 
 0.682
KLRD1
Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
   
  
 0.659
KLRC2
NKG2-C type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
      
 0.602
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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