GZMA protein (Macaca mulatta) - STRING interaction network

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Score

GZMA

Granzyme A; Belongs to the peptidase S1 family. (262 aa)

Predicted Functional Partners:

GNLY

0.891

PRF1

0.889

GZMK

0.864

NKG7

0.850

CD8A

0.813

CD3D

0.805

GZMB

0.804

KLRD1

0.790

CCL5

0.784

IFNG

0.771

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL5	CD8A	ENSMMUP00000073204	ENSMMUP00000004695	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	CD8a molecule.	0.815
CCL5	GNLY	ENSMMUP00000073204	ENSMMUP00000079706	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Uncharacterized protein.	0.585
CCL5	GZMA	ENSMMUP00000073204	ENSMMUP00000002136	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Granzyme A; Belongs to the peptidase S1 family.	0.784
CCL5	GZMB	ENSMMUP00000073204	ENSMMUP00000018888	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Granzyme B; Belongs to the peptidase S1 family.	0.702
CCL5	GZMK	ENSMMUP00000073204	ENSMMUP00000026561	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Granzyme K; Belongs to the peptidase S1 family.	0.570
CCL5	IFNG	ENSMMUP00000073204	ENSMMUP00000065064	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.870
CCL5	KLRD1	ENSMMUP00000073204	ENSMMUP00000024061	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.511
CCL5	NKG7	ENSMMUP00000073204	ENSMMUP00000031485	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Natural killer cell granule protein 7.	0.777
CCL5	PRF1	ENSMMUP00000073204	ENSMMUP00000070226	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	Perforin 1.	0.523
CD3D	CD8A	ENSMMUP00000023161	ENSMMUP00000004695	Ig_4 domain-containing protein.	CD8a molecule.	0.879
CD3D	GNLY	ENSMMUP00000023161	ENSMMUP00000079706	Ig_4 domain-containing protein.	Uncharacterized protein.	0.512
CD3D	GZMA	ENSMMUP00000023161	ENSMMUP00000002136	Ig_4 domain-containing protein.	Granzyme A; Belongs to the peptidase S1 family.	0.805
CD3D	GZMB	ENSMMUP00000023161	ENSMMUP00000018888	Ig_4 domain-containing protein.	Granzyme B; Belongs to the peptidase S1 family.	0.544
CD3D	GZMK	ENSMMUP00000023161	ENSMMUP00000026561	Ig_4 domain-containing protein.	Granzyme K; Belongs to the peptidase S1 family.	0.775
CD3D	KLRD1	ENSMMUP00000023161	ENSMMUP00000024061	Ig_4 domain-containing protein.	Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.	0.415
CD3D	NKG7	ENSMMUP00000023161	ENSMMUP00000031485	Ig_4 domain-containing protein.	Natural killer cell granule protein 7.	0.717
CD3D	PRF1	ENSMMUP00000023161	ENSMMUP00000070226	Ig_4 domain-containing protein.	Perforin 1.	0.409
CD8A	CCL5	ENSMMUP00000004695	ENSMMUP00000073204	CD8a molecule.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.815
CD8A	CD3D	ENSMMUP00000004695	ENSMMUP00000023161	CD8a molecule.	Ig_4 domain-containing protein.	0.879
CD8A	GNLY	ENSMMUP00000004695	ENSMMUP00000079706	CD8a molecule.	Uncharacterized protein.	0.572