Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ERBB4Receptor protein-tyrosine kinase. (1308 aa)    
Predicted Functional Partners:
ERBB2
Receptor protein-tyrosine kinase.
  
0.999
NRG1
Neuregulin 1.
    
 0.999
NRG2
Neuregulin 2.
    
 0.998
GRB2
Growth factor receptor-bound protein 2 isoform 1.
    
 0.997
HBEGF
EGF-like domain-containing protein.
    
 0.995
SHC1
SHC-transforming protein 1 isoform 3.
    
 0.994
NRG4
Neuregulin 4.
    
 0.994
EREG
Proepiregulin.
    
 0.992
BTC
Betacellulin.
    
 0.991
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.989
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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