node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYP1A1 | CYP1A2 | ENSMMUP00000029575 | ENSMMUP00000028750 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.519 |
CYP1A1 | CYP2B6 | ENSMMUP00000029575 | ENSMMUP00000024146 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | 0.939 |
CYP1A1 | CYP3A4 | ENSMMUP00000029575 | ENSMMUP00000004730 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Uncharacterized protein. | 0.951 |
CYP1A1 | CYP7A1 | ENSMMUP00000029575 | ENSMMUP00000008613 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.962 |
CYP1A1 | NR1I2 | ENSMMUP00000029575 | ENSMMUP00000002638 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By s [...] | 0.663 |
CYP1A1 | UGT1A1 | ENSMMUP00000029575 | ENSMMUP00000027940 | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. | 0.976 |
CYP1A2 | CYP1A1 | ENSMMUP00000028750 | ENSMMUP00000029575 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.519 |
CYP1A2 | CYP2B6 | ENSMMUP00000028750 | ENSMMUP00000024146 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | 0.543 |
CYP1A2 | CYP3A4 | ENSMMUP00000028750 | ENSMMUP00000004730 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Uncharacterized protein. | 0.521 |
CYP1A2 | CYP7A1 | ENSMMUP00000028750 | ENSMMUP00000008613 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.520 |
CYP1A2 | NR1I2 | ENSMMUP00000028750 | ENSMMUP00000002638 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By s [...] | 0.755 |
CYP1A2 | UGT1A1 | ENSMMUP00000028750 | ENSMMUP00000027940 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. | 0.789 |
CYP2B6 | CYP1A1 | ENSMMUP00000024146 | ENSMMUP00000029575 | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.939 |
CYP2B6 | CYP1A2 | ENSMMUP00000024146 | ENSMMUP00000028750 | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.543 |
CYP2B6 | CYP3A4 | ENSMMUP00000024146 | ENSMMUP00000004730 | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | Uncharacterized protein. | 0.947 |
CYP2B6 | CYP7A1 | ENSMMUP00000024146 | ENSMMUP00000008613 | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. | 0.613 |
CYP2B6 | NR1I2 | ENSMMUP00000024146 | ENSMMUP00000002638 | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By s [...] | 0.691 |
CYP2B6 | UGT1A1 | ENSMMUP00000024146 | ENSMMUP00000027940 | Cytochrome P450 CYP2B30; Belongs to the cytochrome P450 family. | UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family. | 0.876 |
CYP3A4 | CYP1A1 | ENSMMUP00000004730 | ENSMMUP00000029575 | Uncharacterized protein. | Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] | 0.951 |
CYP3A4 | CYP1A2 | ENSMMUP00000004730 | ENSMMUP00000028750 | Uncharacterized protein. | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.521 |