| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | SPOP | ENSMMUP00000015004 | ENSMMUP00000059498 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Speckle type BTB/POZ protein. | 0.865 |
| AR | SPOPL | ENSMMUP00000015004 | ENSMMUP00000003441 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Speckle-type POZ protein-like. | 0.763 |
| CD274 | CUL3 | ENSMMUP00000039207 | ENSMMUP00000037501 | CD274 molecule. | Cullin-3; Belongs to the cullin family. | 0.801 |
| CD274 | SPOP | ENSMMUP00000039207 | ENSMMUP00000059498 | CD274 molecule. | Speckle type BTB/POZ protein. | 0.889 |
| CD274 | SPOPL | ENSMMUP00000039207 | ENSMMUP00000003441 | CD274 molecule. | Speckle-type POZ protein-like. | 0.763 |
| CUL3 | CD274 | ENSMMUP00000037501 | ENSMMUP00000039207 | Cullin-3; Belongs to the cullin family. | CD274 molecule. | 0.801 |
| CUL3 | GLI1 | ENSMMUP00000037501 | ENSMMUP00000029053 | Cullin-3; Belongs to the cullin family. | Zinc finger protein GLI1 isoform 1. | 0.958 |
| CUL3 | GLI2 | ENSMMUP00000037501 | ENSMMUP00000057562 | Cullin-3; Belongs to the cullin family. | GLI family zinc finger 2. | 0.963 |
| CUL3 | GLI3 | ENSMMUP00000037501 | ENSMMUP00000067447 | Cullin-3; Belongs to the cullin family. | GLI family zinc finger 3. | 0.963 |
| CUL3 | RBX1 | ENSMMUP00000037501 | ENSMMUP00000056775 | Cullin-3; Belongs to the cullin family. | E3 ubiquitin-protein ligase RBX1. | 0.998 |
| CUL3 | SPOP | ENSMMUP00000037501 | ENSMMUP00000059498 | Cullin-3; Belongs to the cullin family. | Speckle type BTB/POZ protein. | 0.998 |
| CUL3 | SPOPL | ENSMMUP00000037501 | ENSMMUP00000003441 | Cullin-3; Belongs to the cullin family. | Speckle-type POZ protein-like. | 0.995 |
| CUL3 | SUFU | ENSMMUP00000037501 | ENSMMUP00000005874 | Cullin-3; Belongs to the cullin family. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.953 |
| GLI1 | CUL3 | ENSMMUP00000029053 | ENSMMUP00000037501 | Zinc finger protein GLI1 isoform 1. | Cullin-3; Belongs to the cullin family. | 0.958 |
| GLI1 | GLI2 | ENSMMUP00000029053 | ENSMMUP00000057562 | Zinc finger protein GLI1 isoform 1. | GLI family zinc finger 2. | 0.990 |
| GLI1 | GLI3 | ENSMMUP00000029053 | ENSMMUP00000067447 | Zinc finger protein GLI1 isoform 1. | GLI family zinc finger 3. | 0.985 |
| GLI1 | RBX1 | ENSMMUP00000029053 | ENSMMUP00000056775 | Zinc finger protein GLI1 isoform 1. | E3 ubiquitin-protein ligase RBX1. | 0.421 |
| GLI1 | SPOP | ENSMMUP00000029053 | ENSMMUP00000059498 | Zinc finger protein GLI1 isoform 1. | Speckle type BTB/POZ protein. | 0.971 |
| GLI1 | SPOPL | ENSMMUP00000029053 | ENSMMUP00000003441 | Zinc finger protein GLI1 isoform 1. | Speckle-type POZ protein-like. | 0.974 |
| GLI1 | SUFU | ENSMMUP00000029053 | ENSMMUP00000005874 | Zinc finger protein GLI1 isoform 1. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.999 |
