STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTCH1Patched 1. (1452 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.999
SHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.999
IHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.996
CDON
Cell adhesion associated, oncogene regulated.
    
 0.995
DHH
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
 0.993
GAS1
Growth arrest specific 1.
     
 0.990
BOC
BOC cell adhesion associated, oncogene regulated.
    
 0.984
SMURF2
E3 ubiquitin-protein ligase.
    
 0.976
GLI1
Zinc finger protein GLI1 isoform 1.
   
 0.944
LRP2
LDL receptor related protein 2.
   
 
 0.924
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.