STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)    
Predicted Functional Partners:
CCNA2
Cyclin-A2; Belongs to the cyclin family.
   
 0.981
CCNE1
Cyclin E1; Belongs to the cyclin family.
   
 0.974
CCNA1
Cyclin-A1 isoform a; Belongs to the cyclin family.
   
 0.974
CCNE2
Cyclin E2; Belongs to the cyclin family.
   
 0.970
SKP2
S-phase kinase-associated protein 2 isoform 1.
   
 0.960
CDC6
Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.
   
 0.930
RB1
Retinoblastoma-associated protein.
   
 0.928
SKP1-2
Uncharacterized protein; Belongs to the SKP1 family.
    
 0.918
CDKN3
Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.
   
 
 0.913
CCND1
Uncharacterized protein; Belongs to the cyclin family.
   
 0.906
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.