STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SIGLEC15Sialic acid binding Ig like lectin 15. (328 aa)    
Predicted Functional Partners:
TYROBP
TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...]
   
 0.899
MAG
CD22 molecule.
    
 0.731
SIGLEC1
Sialic acid binding Ig like lectin 1.
    
 0.728
CD300LB
CD300 molecule like family member b.
    
 0.578
AKIRIN2
Akirin 2.
    
 
 0.538
SIAE
Sialic acid acetylesterase.
      
 0.478
RAB7B
Ras-related protein Rab-7b.
      
 0.473
CRTAM
Cytotoxic and regulatory T cell molecule.
   
 
 0.465
CD47
CD47 molecule.
    
 0.452
B3GALNT1
Hexosyltransferase.
      
 0.420
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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