STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)    
Predicted Functional Partners:
GNAQ
Guanine nucleotide-binding protein G(Q) subunit alpha.
    
 0.979
GNA11
Guanine nucleotide-binding protein subunit alpha-11.
   
 0.965
GNA14
G protein subunit alpha 14.
   
 0.958
GNA15
Uncharacterized protein.
    
 0.957
GNB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.
   
 
 0.952
GNAO1
Guanine nucleotide-binding protein G(O) subunit alpha isoform a.
   
 0.948
PRKCA
Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
   
 
 0.945
GNG13
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
     
 0.941
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
   
 0.934
GNAI2
Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1.
   
 0.934
Your Current Organism:
Macaca mulatta
NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys
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