CDKL5 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP4E1	CDKL5	ENSMMUP00000019879	ENSMMUP00000060517	AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.	Cyclin dependent kinase like 5.	0.630
BLOC1S4	CDKL5	ENSMMUP00000076425	ENSMMUP00000060517	Biogenesis of lysosomal organelles complex 1 subunit 4.	Cyclin dependent kinase like 5.	0.643
CDKL5	AP4E1	ENSMMUP00000060517	ENSMMUP00000019879	Cyclin dependent kinase like 5.	AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.	0.630
CDKL5	BLOC1S4	ENSMMUP00000060517	ENSMMUP00000076425	Cyclin dependent kinase like 5.	Biogenesis of lysosomal organelles complex 1 subunit 4.	0.643
CDKL5	FMR1	ENSMMUP00000060517	ENSMMUP00000058618	Cyclin dependent kinase like 5.	Fragile X mental retardation 1 protein isoform ISO1.	0.711
CDKL5	FOXG1	ENSMMUP00000060517	ENSMMUP00000028245	Cyclin dependent kinase like 5.	Forkhead box G1.	0.753
CDKL5	KCNQ2	ENSMMUP00000060517	ENSMMUP00000020944	Cyclin dependent kinase like 5.	Potassium voltage-gated channel subfamily Q member 2.	0.668
CDKL5	MECP2	ENSMMUP00000060517	ENSMMUP00000055953	Cyclin dependent kinase like 5.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.884
CDKL5	PCDH19	ENSMMUP00000060517	ENSMMUP00000014506	Cyclin dependent kinase like 5.	Protocadherin-19 isoform c.	0.674
CDKL5	SCN1A	ENSMMUP00000060517	ENSMMUP00000052582	Cyclin dependent kinase like 5.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.719
CDKL5	SCN2A	ENSMMUP00000060517	ENSMMUP00000003651	Cyclin dependent kinase like 5.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.671
CDKL5	STXBP1	ENSMMUP00000060517	ENSMMUP00000021567	Cyclin dependent kinase like 5.	Syntaxin-binding protein 1 isoform a; Belongs to the STXBP/unc-18/SEC1 family.	0.670
FMR1	CDKL5	ENSMMUP00000058618	ENSMMUP00000060517	Fragile X mental retardation 1 protein isoform ISO1.	Cyclin dependent kinase like 5.	0.711
FMR1	MECP2	ENSMMUP00000058618	ENSMMUP00000055953	Fragile X mental retardation 1 protein isoform ISO1.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.854
FMR1	SCN1A	ENSMMUP00000058618	ENSMMUP00000052582	Fragile X mental retardation 1 protein isoform ISO1.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.433
FOXG1	CDKL5	ENSMMUP00000028245	ENSMMUP00000060517	Forkhead box G1.	Cyclin dependent kinase like 5.	0.753
FOXG1	MECP2	ENSMMUP00000028245	ENSMMUP00000055953	Forkhead box G1.	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).	0.822
KCNQ2	CDKL5	ENSMMUP00000020944	ENSMMUP00000060517	Potassium voltage-gated channel subfamily Q member 2.	Cyclin dependent kinase like 5.	0.668
KCNQ2	PCDH19	ENSMMUP00000020944	ENSMMUP00000014506	Potassium voltage-gated channel subfamily Q member 2.	Protocadherin-19 isoform c.	0.710
KCNQ2	SCN1A	ENSMMUP00000020944	ENSMMUP00000052582	Potassium voltage-gated channel subfamily Q member 2.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.703