RGS4 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C14H11orf87	RGS4	ENSMMUP00000057905	ENSMMUP00000006859	Uncharacterized protein C11orf87.	Regulator of G protein signaling 4.	0.692
EGFR	RGS4	ENSMMUP00000046120	ENSMMUP00000006859	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Regulator of G protein signaling 4.	0.756
GNA11	GNA14	ENSMMUP00000003957	ENSMMUP00000022417	Guanine nucleotide-binding protein subunit alpha-11.	G protein subunit alpha 14.	0.900
GNA11	GNAI1	ENSMMUP00000003957	ENSMMUP00000030898	Guanine nucleotide-binding protein subunit alpha-11.	G protein subunit alpha i1.	0.584
GNA11	GNAI2	ENSMMUP00000003957	ENSMMUP00000026482	Guanine nucleotide-binding protein subunit alpha-11.	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1.	0.930
GNA11	GNAI3	ENSMMUP00000003957	ENSMMUP00000007669	Guanine nucleotide-binding protein subunit alpha-11.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.934
GNA11	GNAO1	ENSMMUP00000003957	ENSMMUP00000026159	Guanine nucleotide-binding protein subunit alpha-11.	Guanine nucleotide-binding protein G(O) subunit alpha isoform a.	0.540
GNA11	GNAQ	ENSMMUP00000003957	ENSMMUP00000061851	Guanine nucleotide-binding protein subunit alpha-11.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.965
GNA11	GNAT3	ENSMMUP00000003957	ENSMMUP00000078198	Guanine nucleotide-binding protein subunit alpha-11.	G protein subunit alpha transducin 3.	0.918
GNA11	RGS4	ENSMMUP00000003957	ENSMMUP00000006859	Guanine nucleotide-binding protein subunit alpha-11.	Regulator of G protein signaling 4.	0.710
GNA14	GNA11	ENSMMUP00000022417	ENSMMUP00000003957	G protein subunit alpha 14.	Guanine nucleotide-binding protein subunit alpha-11.	0.900
GNA14	GNAI1	ENSMMUP00000022417	ENSMMUP00000030898	G protein subunit alpha 14.	G protein subunit alpha i1.	0.583
GNA14	GNAI2	ENSMMUP00000022417	ENSMMUP00000026482	G protein subunit alpha 14.	Guanine nucleotide-binding protein G(I) subunit alpha-2 isoform 1.	0.931
GNA14	GNAI3	ENSMMUP00000022417	ENSMMUP00000007669	G protein subunit alpha 14.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.935
GNA14	GNAO1	ENSMMUP00000022417	ENSMMUP00000026159	G protein subunit alpha 14.	Guanine nucleotide-binding protein G(O) subunit alpha isoform a.	0.540
GNA14	GNAQ	ENSMMUP00000022417	ENSMMUP00000061851	G protein subunit alpha 14.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.965
GNA14	GNAT3	ENSMMUP00000022417	ENSMMUP00000078198	G protein subunit alpha 14.	G protein subunit alpha transducin 3.	0.918
GNA14	RGS4	ENSMMUP00000022417	ENSMMUP00000006859	G protein subunit alpha 14.	Regulator of G protein signaling 4.	0.710
GNAI1	GNA11	ENSMMUP00000030898	ENSMMUP00000003957	G protein subunit alpha i1.	Guanine nucleotide-binding protein subunit alpha-11.	0.584
GNAI1	GNA14	ENSMMUP00000030898	ENSMMUP00000022417	G protein subunit alpha i1.	G protein subunit alpha 14.	0.583