PIK3CA protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PIK3CA

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)

Predicted Functional Partners:

PIK3R1

0.999

PIK3R2

0.996

PIK3R3

0.995

RRAS

0.994

KRAS

0.993

MRAS

0.993

EGFR

0.992

PIK3R5

0.989

IRS1

0.987

NRAS

0.987

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	IRS1	ENSMMUP00000046120	ENSMMUP00000045227	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Insulin receptor substrate 1.	0.813
EGFR	KRAS	ENSMMUP00000046120	ENSMMUP00000002635	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	KRAS proto-oncogene, GTPase.	0.986
EGFR	NRAS	ENSMMUP00000046120	ENSMMUP00000050401	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	NRAS proto-oncogene, GTPase.	0.975
EGFR	PIK3CA	ENSMMUP00000046120	ENSMMUP00000006866	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.992
EGFR	PIK3R1	ENSMMUP00000046120	ENSMMUP00000015140	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphoinositide-3-kinase regulatory subunit 1.	0.990
EGFR	PIK3R2	ENSMMUP00000046120	ENSMMUP00000004228	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.975
EGFR	PIK3R3	ENSMMUP00000046120	ENSMMUP00000060463	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	Uncharacterized protein.	0.974
IRS1	EGFR	ENSMMUP00000045227	ENSMMUP00000046120	Insulin receptor substrate 1.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.813
IRS1	PIK3CA	ENSMMUP00000045227	ENSMMUP00000006866	Insulin receptor substrate 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.987
IRS1	PIK3R1	ENSMMUP00000045227	ENSMMUP00000015140	Insulin receptor substrate 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.996
IRS1	PIK3R2	ENSMMUP00000045227	ENSMMUP00000004228	Insulin receptor substrate 1.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.973
IRS1	PIK3R3	ENSMMUP00000045227	ENSMMUP00000060463	Insulin receptor substrate 1.	Uncharacterized protein.	0.983
IRS1	PIK3R5	ENSMMUP00000045227	ENSMMUP00000007641	Insulin receptor substrate 1.	Phosphoinositide-3-kinase regulatory subunit 5.	0.934
KRAS	EGFR	ENSMMUP00000002635	ENSMMUP00000046120	KRAS proto-oncogene, GTPase.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...]	0.986
KRAS	NRAS	ENSMMUP00000002635	ENSMMUP00000050401	KRAS proto-oncogene, GTPase.	NRAS proto-oncogene, GTPase.	0.917
KRAS	PIK3CA	ENSMMUP00000002635	ENSMMUP00000006866	KRAS proto-oncogene, GTPase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.993
KRAS	PIK3R1	ENSMMUP00000002635	ENSMMUP00000015140	KRAS proto-oncogene, GTPase.	Phosphoinositide-3-kinase regulatory subunit 1.	0.954
KRAS	PIK3R2	ENSMMUP00000002635	ENSMMUP00000004228	KRAS proto-oncogene, GTPase.	Phosphatidylinositol 3-kinase regulatory subunit beta.	0.941
KRAS	PIK3R3	ENSMMUP00000002635	ENSMMUP00000060463	KRAS proto-oncogene, GTPase.	Uncharacterized protein.	0.945
KRAS	PIK3R5	ENSMMUP00000002635	ENSMMUP00000007641	KRAS proto-oncogene, GTPase.	Phosphoinositide-3-kinase regulatory subunit 5.	0.918