node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | FGFR2 | ENSMMUP00000046120 | ENSMMUP00000048184 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | Fibroblast growth factor receptor. | 0.415 |
EGFR | ITK | ENSMMUP00000046120 | ENSMMUP00000014407 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | Tyrosine-protein kinase. | 0.509 |
EGFR | NTRK1 | ENSMMUP00000046120 | ENSMMUP00000016316 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | Tyrosine-protein kinase receptor. | 0.421 |
EGFR | NTRK2 | ENSMMUP00000046120 | ENSMMUP00000073592 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | Tyrosine-protein kinase receptor. | 0.567 |
EGFR | PDGFRB | ENSMMUP00000046120 | ENSMMUP00000015166 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. | 0.973 |
EGFR | PLCG1 | ENSMMUP00000046120 | ENSMMUP00000056589 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.987 |
EGFR | VAV1 | ENSMMUP00000046120 | ENSMMUP00000058900 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | Vav guanine nucleotide exchange factor 1. | 0.584 |
FGFR2 | EGFR | ENSMMUP00000048184 | ENSMMUP00000046120 | Fibroblast growth factor receptor. | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | 0.415 |
FGFR2 | PLCG1 | ENSMMUP00000048184 | ENSMMUP00000056589 | Fibroblast growth factor receptor. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.989 |
ITK | EGFR | ENSMMUP00000014407 | ENSMMUP00000046120 | Tyrosine-protein kinase. | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | 0.509 |
ITK | LAT | ENSMMUP00000014407 | ENSMMUP00000059965 | Tyrosine-protein kinase. | Uncharacterized protein. | 0.868 |
ITK | LCP2 | ENSMMUP00000014407 | ENSMMUP00000057834 | Tyrosine-protein kinase. | Lymphocyte cytosolic protein 2. | 0.992 |
ITK | PLCG1 | ENSMMUP00000014407 | ENSMMUP00000056589 | Tyrosine-protein kinase. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.980 |
ITK | SYK | ENSMMUP00000014407 | ENSMMUP00000063860 | Tyrosine-protein kinase. | Tyrosine-protein kinase. | 0.563 |
ITK | VAV1 | ENSMMUP00000014407 | ENSMMUP00000058900 | Tyrosine-protein kinase. | Vav guanine nucleotide exchange factor 1. | 0.985 |
LAT | ITK | ENSMMUP00000059965 | ENSMMUP00000014407 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.868 |
LAT | LCP2 | ENSMMUP00000059965 | ENSMMUP00000057834 | Uncharacterized protein. | Lymphocyte cytosolic protein 2. | 0.876 |
LAT | PLCG1 | ENSMMUP00000059965 | ENSMMUP00000056589 | Uncharacterized protein. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. | 0.992 |
LAT | SYK | ENSMMUP00000059965 | ENSMMUP00000063860 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.872 |
LAT | VAV1 | ENSMMUP00000059965 | ENSMMUP00000058900 | Uncharacterized protein. | Vav guanine nucleotide exchange factor 1. | 0.754 |