| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CASP1 | CTSB | ENSMMUP00000066498 | ENSMMUP00000067393 | Caspase 1; Belongs to the peptidase C14A family. | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | 0.613 |
| CASP1 | GSDMD | ENSMMUP00000066498 | ENSMMUP00000031883 | Caspase 1; Belongs to the peptidase C14A family. | Gasdermin D. | 0.995 |
| CASP1 | IL1B | ENSMMUP00000066498 | ENSMMUP00000079493 | Caspase 1; Belongs to the peptidase C14A family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.997 |
| CASP1 | MAVS | ENSMMUP00000066498 | ENSMMUP00000022556 | Caspase 1; Belongs to the peptidase C14A family. | Mitochondrial antiviral-signaling protein isoform 1. | 0.549 |
| CASP1 | NEK7 | ENSMMUP00000066498 | ENSMMUP00000028509 | Caspase 1; Belongs to the peptidase C14A family. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.581 |
| CASP1 | NLRP3 | ENSMMUP00000066498 | ENSMMUP00000053959 | Caspase 1; Belongs to the peptidase C14A family. | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] | 0.981 |
| CASP1 | PYCARD | ENSMMUP00000066498 | ENSMMUP00000073338 | Caspase 1; Belongs to the peptidase C14A family. | Apoptosis-associated speck-like protein containing a CARD isoform a. | 0.999 |
| CASP1 | TXNIP | ENSMMUP00000066498 | ENSMMUP00000076642 | Caspase 1; Belongs to the peptidase C14A family. | Thioredoxin-interacting protein. | 0.525 |
| CTSB | CASP1 | ENSMMUP00000067393 | ENSMMUP00000066498 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | Caspase 1; Belongs to the peptidase C14A family. | 0.613 |
| CTSB | IL1B | ENSMMUP00000067393 | ENSMMUP00000079493 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.562 |
| CTSB | NLRP3 | ENSMMUP00000067393 | ENSMMUP00000053959 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] | 0.961 |
| GSDMD | CASP1 | ENSMMUP00000031883 | ENSMMUP00000066498 | Gasdermin D. | Caspase 1; Belongs to the peptidase C14A family. | 0.995 |
| GSDMD | IL1B | ENSMMUP00000031883 | ENSMMUP00000079493 | Gasdermin D. | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | 0.863 |
| GSDMD | NEK7 | ENSMMUP00000031883 | ENSMMUP00000028509 | Gasdermin D. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.633 |
| GSDMD | NLRP3 | ENSMMUP00000031883 | ENSMMUP00000053959 | Gasdermin D. | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] | 0.961 |
| GSDMD | PYCARD | ENSMMUP00000031883 | ENSMMUP00000073338 | Gasdermin D. | Apoptosis-associated speck-like protein containing a CARD isoform a. | 0.786 |
| HSP90AA1 | NLRP3 | ENSMMUP00000080725 | ENSMMUP00000053959 | HATPase_c domain-containing protein. | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (By similarity). The ac [...] | 0.955 |
| HSP90AA1 | SLC29A1 | ENSMMUP00000080725 | ENSMMUP00000075454 | HATPase_c domain-containing protein. | HATPase_c domain-containing protein. | 0.990 |
| IL1B | CASP1 | ENSMMUP00000079493 | ENSMMUP00000066498 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Caspase 1; Belongs to the peptidase C14A family. | 0.997 |
| IL1B | CTSB | ENSMMUP00000079493 | ENSMMUP00000067393 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. | 0.562 |
STRING v12.5 is now available!
