CLSTN1 protein (Macaca mulatta) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBA2	APP	ENSMMUP00000051185	ENSMMUP00000018894	Amyloid beta A4 protein-binding family A member 2 isoform a.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.868
APBA2	CLSTN1	ENSMMUP00000051185	ENSMMUP00000008184	Amyloid beta A4 protein-binding family A member 2 isoform a.	Calsyntenin 1.	0.795
APP	APBA2	ENSMMUP00000018894	ENSMMUP00000051185	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Amyloid beta A4 protein-binding family A member 2 isoform a.	0.868
APP	CLSTN1	ENSMMUP00000018894	ENSMMUP00000008184	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Calsyntenin 1.	0.820
APP	KLC1	ENSMMUP00000018894	ENSMMUP00000022374	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Uncharacterized protein.	0.757
APP	KLC2	ENSMMUP00000018894	ENSMMUP00000037580	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Kinesin light chain 2.	0.693
APP	KLC4	ENSMMUP00000018894	ENSMMUP00000015314	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Kinesin light chain 4.	0.650
APP	PRNP	ENSMMUP00000018894	ENSMMUP00000064194	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...]	0.945
CDK18	CLSTN1	ENSMMUP00000005492	ENSMMUP00000008184	Cyclin-dependent kinase 18 isoform b; Belongs to the protein kinase superfamily.	Calsyntenin 1.	0.674
CLSTN1	APBA2	ENSMMUP00000008184	ENSMMUP00000051185	Calsyntenin 1.	Amyloid beta A4 protein-binding family A member 2 isoform a.	0.795
CLSTN1	APP	ENSMMUP00000008184	ENSMMUP00000018894	Calsyntenin 1.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.820
CLSTN1	CDK18	ENSMMUP00000008184	ENSMMUP00000005492	Calsyntenin 1.	Cyclin-dependent kinase 18 isoform b; Belongs to the protein kinase superfamily.	0.674
CLSTN1	KLC1	ENSMMUP00000008184	ENSMMUP00000022374	Calsyntenin 1.	Uncharacterized protein.	0.811
CLSTN1	KLC2	ENSMMUP00000008184	ENSMMUP00000037580	Calsyntenin 1.	Kinesin light chain 2.	0.864
CLSTN1	KLC4	ENSMMUP00000008184	ENSMMUP00000015314	Calsyntenin 1.	Kinesin light chain 4.	0.753
CLSTN1	PNO1	ENSMMUP00000008184	ENSMMUP00000022985	Calsyntenin 1.	Uncharacterized protein.	0.585
CLSTN1	PRNP	ENSMMUP00000008184	ENSMMUP00000064194	Calsyntenin 1.	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...]	0.727
CLSTN1	TLN1	ENSMMUP00000008184	ENSMMUP00000058740	Calsyntenin 1.	Talin 1.	0.652
CLSTN1	TNS1	ENSMMUP00000008184	ENSMMUP00000065176	Calsyntenin 1.	Tensin 1.	0.592
KLC1	APP	ENSMMUP00000022374	ENSMMUP00000018894	Uncharacterized protein.	Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those mediated by G(O) an [...]	0.757