PRLR protein (Macaca mulatta) - STRING interaction network

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Score

PRLR

Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (619 aa)

Predicted Functional Partners:

PRL

0.999

JAK2

0.998

STAT5A

0.980

STAT5B

0.978

LEPR

0.965

KANK1

0.963

STAT3

0.962

LOC114669853

0.953

GHR

0.952

JAK1

0.948

Your Current Organism:

Macaca mulatta

NCBI taxonomy Id: 9544
Other names: M. mulatta, Rhesus monkey, rhesus macaque, rhesus macaques, rhesus monkeys

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GHR	JAK1	ENSMMUP00000001786	ENSMMUP00000024423	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Tyrosine-protein kinase.	0.940
GHR	JAK2	ENSMMUP00000001786	ENSMMUP00000019119	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Tyrosine-protein kinase.	0.997
GHR	LEPR	ENSMMUP00000001786	ENSMMUP00000004351	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...]	0.937
GHR	LOC114669853	ENSMMUP00000001786	ENSMMUP00000062520	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Tyrosine-protein kinase.	0.966
GHR	PRL	ENSMMUP00000001786	ENSMMUP00000027172	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.	0.960
GHR	PRLR	ENSMMUP00000001786	ENSMMUP00000008301	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.952
GHR	STAT3	ENSMMUP00000001786	ENSMMUP00000043986	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Signal transducer and activator of transcription.	0.956
GHR	STAT5A	ENSMMUP00000001786	ENSMMUP00000050038	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Signal transducer and activator of transcription.	0.980
GHR	STAT5B	ENSMMUP00000001786	ENSMMUP00000004582	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	Signal transducer and activator of transcription.	0.989
JAK1	GHR	ENSMMUP00000024423	ENSMMUP00000001786	Tyrosine-protein kinase.	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	0.940
JAK1	JAK2	ENSMMUP00000024423	ENSMMUP00000019119	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.995
JAK1	LEPR	ENSMMUP00000024423	ENSMMUP00000004351	Tyrosine-protein kinase.	Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...]	0.531
JAK1	LOC114669853	ENSMMUP00000024423	ENSMMUP00000062520	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.987
JAK1	PRL	ENSMMUP00000024423	ENSMMUP00000027172	Tyrosine-protein kinase.	Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation.	0.820
JAK1	PRLR	ENSMMUP00000024423	ENSMMUP00000008301	Tyrosine-protein kinase.	Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin.	0.948
JAK1	STAT3	ENSMMUP00000024423	ENSMMUP00000043986	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.998
JAK1	STAT5A	ENSMMUP00000024423	ENSMMUP00000050038	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.993
JAK1	STAT5B	ENSMMUP00000024423	ENSMMUP00000004582	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.991
JAK2	GHR	ENSMMUP00000019119	ENSMMUP00000001786	Tyrosine-protein kinase.	Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity).	0.997
JAK2	JAK1	ENSMMUP00000019119	ENSMMUP00000024423	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.995